{"id":"W3162448264","doi":"10.1002/cjce.24197","title":"Recent advances and current challenges in process intensification of cell culture‐based influenza virus vaccine manufacturing","year":2021,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vaccination; Flexibility (engineering); Pandemic; Influenza vaccine; Production (economics); Business; Population; Productivity; Virology; Biotechnology; Coronavirus disease 2019 (COVID-19); Medicine; Biology; Economic growth; Environmental health; Economics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002077403,0.0008364923,0.0006494534,0.0009641571,0.000311206,0.001514554,0.0007563914,0.000930391,0.001938032],"category_scores_gemma":[0.0008817217,0.0004155245,0.0006555454,0.001615489,0.0005596218,0.001654219,0.0006749067,0.001316885,0.0008621226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132188,"about_ca_system_score_gemma":0.00133947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001832194,"about_ca_topic_score_gemma":0.002269528,"domain_scores_codex":[0.9994348,0.00009124843,0.00006622133,0.00009612843,0.0002517418,0.00005980613],"domain_scores_gemma":[0.9992805,0.0002592462,0.0001361122,0.0000375897,0.0002436566,0.00004291421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002441032,0.0002804778,0.001612714,0.02414267,0.0001433277,0.0005907831,0.0004277739,0.006984021,0.2069497,0.01789911,0.00775946,0.7329659],"study_design_scores_gemma":[0.00005421026,0.001257226,0.003623906,0.001759443,0.0003066456,0.001441712,0.0005280176,0.007768026,0.1717875,0.008295998,0.8030486,0.0001287995],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02068134,0.943679,0.02288528,0.001953556,0.0005479595,0.00008006057,0.0001126991,0.0001189459,0.009941062],"genre_scores_gemma":[0.05173327,0.9237312,0.02109294,0.000536912,0.0003661617,0.0000650942,0.0002326067,0.0000281285,0.002213791],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002077403,"threshold_uncertainty_score":0.01098645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711763313829509,"score_gpt":0.2562836671635674,"score_spread":0.2391660340252723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}