{"id":"W3162485228","doi":"10.1038/s41467-021-22973-9","title":"The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":336,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Lupus Research Alliance; National Heart, Lung, and Blood Institute; Gilead Sciences; Boehringer Ingelheim Fonds; National Research Foundation; Fund for Astrophysical Research; Arthritis National Research Foundation; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Transcriptome; Biology; Cell biology; Bone marrow; Spleen; Immunology; Haematopoiesis; Granulocyte; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102579,0.0001020432,0.0001590741,0.0002400407,0.000131481,0.000367205,0.00009808715,0.0001914043,0.0004779436],"category_scores_gemma":[0.0001886747,0.00009582203,0.0001186521,0.0001720683,0.000263017,0.000215941,0.0001894098,0.0002289791,0.0001839799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269774,"about_ca_system_score_gemma":0.0001181959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003736642,"about_ca_topic_score_gemma":0.0009374093,"domain_scores_codex":[0.9998937,0.000009525589,0.000004896213,0.00004891413,0.00002657572,0.00001644569],"domain_scores_gemma":[0.9998734,0.00002701562,0.0000393195,0.00001683742,0.00002220054,0.00002120481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002414396,0.000001516206,0.000749943,0.000007834554,0.000001227434,0.00001272995,0.00001523756,0.00003313961,0.9979689,0.00007941339,0.000006768347,0.001099187],"study_design_scores_gemma":[0.000008019635,0.0002540596,0.1633014,0.00002368775,0.00002419908,0.0007764415,0.0002816343,0.002709453,0.826426,0.001173885,0.005000783,0.00002045912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810801,0.0006513096,0.01588335,0.00007231209,0.000008032592,0.00001678684,0.0008291938,0.00007675443,0.001382],"genre_scores_gemma":[0.9889005,0.000466086,0.008266457,0.00007723659,0.000007290522,0.00003252636,0.0009416641,0.00002752873,0.001280666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004779436,"threshold_uncertainty_score":0.001598895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03740508536458887,"score_gpt":0.2970837752514862,"score_spread":0.2596786898868974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}