{"id":"W3162526259","doi":"10.1101/mcs.a006090","title":"Common clonal origin of chronic myelomonocytic leukemia and B-cell acute lymphoblastic leukemia in a patient with a germline <i>CHEK2</i> variant","year":2021,"lang":"en","type":"article","venue":"Molecular Case Studies","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Fondation de l'Hôpital général juif; Jewish General Hospital","keywords":"Biology; Chronic myelomonocytic leukemia; Germline; Myeloid; Somatic evolution in cancer; Exome sequencing; Germline mutation; Cancer research; Leukemia; Genetics; Exome; CHEK2; Myelodysplastic syndromes; Mutation; Immunology; Cancer; Gene; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126413,0.0008842554,0.0004625297,0.001425199,0.001096064,0.0006777311,0.0005236416,0.001697705,0.002227891],"category_scores_gemma":[0.001174492,0.0004995936,0.0003439229,0.0006610142,0.0008403911,0.0005452039,0.0008780604,0.0008233457,0.0003835458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005457464,"about_ca_system_score_gemma":0.0004766597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002037733,"about_ca_topic_score_gemma":0.002771835,"domain_scores_codex":[0.9997012,0.00003257293,0.00002944379,0.0001142983,0.00004353224,0.00007896507],"domain_scores_gemma":[0.9994711,0.000126239,0.0001010474,0.00003827753,0.00002901871,0.0002342669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001418548,0.00006841984,0.0596829,0.00002796448,0.00001769792,0.9274526,0.000386339,0.0001360695,0.00782937,0.0005452508,0.0004614234,0.003250131],"study_design_scores_gemma":[0.00001689729,0.00008989564,0.02798764,0.00001020531,0.00002034427,0.9691244,0.0001226709,0.0003467438,0.001400947,0.0002252022,0.0006443273,0.00001082683],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948854,0.0003993916,0.0005887513,0.0004377787,0.00002374549,0.00006027428,0.0001965364,0.00004733952,0.003360917],"genre_scores_gemma":[0.9986075,0.0001438146,0.0005171231,0.0001642536,0.00005198206,0.000009917383,0.00008783345,0.00001047695,0.0004071757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227891,"threshold_uncertainty_score":0.007453084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412741002748049,"score_gpt":0.2854065966266141,"score_spread":0.2712791865991336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}