{"id":"W3162526259","doi":"10.1101/mcs.a006090","title":"Common clonal origin of chronic myelomonocytic leukemia and B-cell acute lymphoblastic leukemia in a patient with a germline <i>CHEK2</i> variant","year":2021,"lang":"en","type":"article","venue":"Molecular Case Studies","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Fondation de l'Hôpital général juif; Jewish General Hospital","keywords":"Biology; Chronic myelomonocytic leukemia; Germline; Myeloid; Somatic evolution in cancer; Exome sequencing; Germline mutation; Cancer research; Leukemia; Genetics; Exome; CHEK2; Myelodysplastic syndromes; Mutation; Immunology; Cancer; Gene; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002867649,0.0003942745,0.0009861978,0.0002383326,0.0001033555,0.00002102838,0.00009044237,0.0001284343,0.00002061921],"category_scores_gemma":[0.0001657756,0.000319172,0.0001167199,0.0007398116,0.0004189245,0.0000649355,0.0004144484,0.0004762932,0.000007946334],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004882829,"about_ca_system_score_gemma":0.003848802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004039357,"about_ca_topic_score_gemma":0.0004285552,"domain_scores_codex":[0.9974145,0.0002128284,0.0005871968,0.0006458503,0.0005412485,0.0005983593],"domain_scores_gemma":[0.9984207,0.0002717761,0.0001563179,0.0005670092,0.0003722417,0.0002120213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240783,0.0003106311,0.0009786332,0.001565404,0.00169418,0.8818871,0.001975898,0.001030347,0.1029182,0.0002330313,0.0007691051,0.005396601],"study_design_scores_gemma":[0.05177445,0.008828312,0.001362173,0.003416647,0.003894735,0.3957646,0.006733824,0.05187731,0.4701415,0.0003405828,0.003892173,0.00197371],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850606,0.01276434,0.0005387059,0.0003224974,0.00005210426,0.0005915939,0.00004211174,0.00003287471,0.0005951477],"genre_scores_gemma":[0.9953704,0.001577734,0.00211354,0.0004097715,0.00004792818,0.0001084256,0.00003787549,0.00006253943,0.0002717735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4861225,"threshold_uncertainty_score":0.999926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412741002748049,"score_gpt":0.2854065966266141,"score_spread":0.2712791865991336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}