{"id":"W3162562489","doi":"10.1038/s41467-021-22929-z","title":"Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; McMaster University Medical Centre; Université de Montréal; Children's Hospital of Eastern Ontario; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Foundation; Canadian Cancer Society Research Institute; Alliance for Cancer Gene Therapy; Canadian Institutes of Health Research; Terry Fox Foundation; Institute of Cancer Research; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Virotherapy; Vesicular stomatitis virus; Vaccinia; Vaccination; Cancer; Adjuvant; Cancer vaccine; Antigen; Virology; Virus; Immunology; Medicine; Immunotherapy; Cancer research; Immune system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025208,0.0002797937,0.0002739467,0.0002275709,0.00009501016,0.0004110407,0.0001807723,0.0003403484,0.001678188],"category_scores_gemma":[0.0001544946,0.0001382699,0.0001893408,0.0001320636,0.0002275375,0.000282386,0.0002835366,0.0007297474,0.0005825121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000374446,"about_ca_system_score_gemma":0.0003704775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001608394,"about_ca_topic_score_gemma":0.0003243304,"domain_scores_codex":[0.9998869,0.00003417284,0.000005293023,0.00001761098,0.00003376896,0.00002235664],"domain_scores_gemma":[0.9999583,0.000008573065,0.00001075769,0.00000775881,0.000004967026,0.000009713222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636622,0.0001177308,0.0002207589,0.000215277,0.00001590358,0.00007086352,0.00002798016,0.001613735,0.9643269,0.007279974,0.0008899137,0.02505739],"study_design_scores_gemma":[0.0001104605,0.001140146,0.0008515978,0.00005846254,0.0000520235,0.000662073,0.00002131118,0.01286233,0.8983972,0.002913609,0.08291448,0.00001630644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7021572,0.05827599,0.214928,0.002436638,0.0009934336,0.0005694115,0.0006921217,0.00101245,0.01893488],"genre_scores_gemma":[0.9467404,0.01151563,0.03592676,0.0003490136,0.0001090477,0.0001541323,0.0003151034,0.00005468558,0.004835188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001678188,"threshold_uncertainty_score":0.005614161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03488832594460206,"score_gpt":0.3967715413154485,"score_spread":0.3618832153708464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}