{"id":"W3162562489","doi":"10.1038/s41467-021-22929-z","title":"Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; McMaster University Medical Centre; Université de Montréal; Children's Hospital of Eastern Ontario; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Foundation; Canadian Cancer Society Research Institute; Alliance for Cancer Gene Therapy; Canadian Institutes of Health Research; Terry Fox Foundation; Institute of Cancer Research; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Virotherapy; Vesicular stomatitis virus; Vaccinia; Vaccination; Cancer; Adjuvant; Cancer vaccine; Antigen; Virology; Virus; Immunology; Medicine; Immunotherapy; Cancer research; Immune system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197124,0.0001085157,0.0001283433,0.00004129334,0.0002417831,0.00003250779,0.0005955948,0.0002536295,0.0001330021],"category_scores_gemma":[0.0001337316,0.0001104801,0.0001229252,0.0001802139,0.00005621022,0.000004744489,0.0001386357,0.0002919871,0.000006274122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004637149,"about_ca_system_score_gemma":0.0003061947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003315372,"about_ca_topic_score_gemma":0.0007308659,"domain_scores_codex":[0.9991344,0.0001640051,0.0001417998,0.0002442618,0.0001352687,0.0001802436],"domain_scores_gemma":[0.9981116,0.00006462325,0.00005853553,0.001264311,0.0004478529,0.00005306593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002830604,0.0001799348,0.0004582337,0.00001132238,0.0001158309,2.812123e-7,0.00005379584,0.0000199313,0.9759696,0.001335945,0.006007705,0.01556433],"study_design_scores_gemma":[0.001383513,0.000276682,0.001252167,0.000009570485,0.00001908541,0.000003195682,0.00006022359,0.0003636357,0.5320408,0.0001184211,0.4643174,0.000155339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7557696,0.2080288,0.002846477,0.02796919,0.0003510386,0.001670879,0.0004719898,0.00007429377,0.002817733],"genre_scores_gemma":[0.9706066,0.01817679,0.003580428,0.001987286,0.0001823311,0.0004602036,0.001038003,0.00004128723,0.003927033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4583097,"threshold_uncertainty_score":0.4505247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03488832594460206,"score_gpt":0.3967715413154485,"score_spread":0.3618832153708464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}