{"id":"W3162635089","doi":"10.1126/science.aaz2740","title":"Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; American Lebanese Syrian Associated Charities; Harvard Catalyst; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Cancer Research Institute","keywords":"Transcription factor; Biology; Cell biology; Pyrimidine metabolism; Dihydroorotate dehydrogenase; Mitochondrion; Transcriptional regulation; Transcription (linguistics); Zebrafish; Histone; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197055,0.0003349919,0.0002143745,0.000280612,0.0002059791,0.000471697,0.0004045382,0.0004443211,0.001344614],"category_scores_gemma":[0.0001905121,0.0003377631,0.0002085881,0.0001795704,0.0005167927,0.0002284291,0.0004545245,0.001024171,0.0006235651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007486959,"about_ca_system_score_gemma":0.0003450905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000851293,"about_ca_topic_score_gemma":0.002125064,"domain_scores_codex":[0.9998263,0.00001405434,0.00001305651,0.00004873697,0.00006169979,0.00003618161],"domain_scores_gemma":[0.9998288,0.00003412384,0.00005368852,0.00002730836,0.00001976692,0.00003635094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000249162,0.000005661411,0.0001085872,0.00001344238,0.000001596972,0.00002766399,0.00001617041,0.00005747262,0.9979235,0.0004183606,0.00007187436,0.001330855],"study_design_scores_gemma":[0.00001126878,0.00003631704,0.002679119,0.000006986597,0.000006329357,0.00009759645,0.00002987863,0.0009755648,0.9913443,0.0002281404,0.004579075,0.000005341109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708486,0.003699101,0.01300231,0.0009710675,0.0001732941,0.00004230984,0.0007476351,0.0004325258,0.01008324],"genre_scores_gemma":[0.9889414,0.001427569,0.002622888,0.0001838805,0.00002216873,0.00001971944,0.0004526021,0.00009276644,0.006237076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344614,"threshold_uncertainty_score":0.005432189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006003593505126827,"score_gpt":0.2280253692035386,"score_spread":0.2220217756984118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}