{"id":"W3162723760","doi":"10.1101/2020.10.15.338160","title":"Beta-cell specific <i>Insr</i> deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Alberta; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Insulin resistance; Insulin; Knockout mouse; Impaired glucose tolerance; Glucose tolerance test; Receptor; Diabetes mellitus; Insulin oscillation; Pancreatic hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866133,0.000785934,0.0005763472,0.0003297985,0.0001325734,0.0004591719,0.0003338308,0.0003676705,0.003789661],"category_scores_gemma":[0.0001258932,0.0002938882,0.0005208195,0.0001692575,0.0003235389,0.0003386597,0.0003143301,0.001503578,0.001246856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462193,"about_ca_system_score_gemma":0.0001110335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002581447,"about_ca_topic_score_gemma":0.0003309122,"domain_scores_codex":[0.9997914,0.00002202328,0.00002585945,0.00006305399,0.00004463376,0.00005301067],"domain_scores_gemma":[0.9996499,0.00002813662,0.0001481125,0.00003746285,0.0000183184,0.0001180557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002639295,0.00005208339,0.0002229681,0.00002945531,0.00000923562,0.00004818204,0.00000878247,0.00004736647,0.9980534,0.0000589134,0.00008336566,0.001122275],"study_design_scores_gemma":[0.0000738845,0.001560156,0.01781025,0.00003673268,0.00008705423,0.0006076446,0.0001064097,0.00125784,0.9724634,0.0001071258,0.005865573,0.0000240258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888024,0.0008471013,0.005647538,0.0001985656,0.0001113646,0.00003283472,0.001819407,0.0004797318,0.002061072],"genre_scores_gemma":[0.9837644,0.001082472,0.003312659,0.0002919317,0.00005294422,0.00009795924,0.002296141,0.0004553408,0.008646073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003789661,"threshold_uncertainty_score":0.01267767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335070431613378,"score_gpt":0.2148305792427658,"score_spread":0.201479874926632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}