{"id":"W3162741821","doi":"10.1038/s41590-021-00928-y","title":"Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Histone H3; Biology; Chromatin; Cell biology; Monocyte; Histone; Cellular differentiation; Proteases; Chromatin remodeling; Molecular biology; Immunology; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002257955,0.0002984138,0.0005996148,0.0002103334,0.0001567061,0.00001221537,0.0002988285,0.001424873,0.0005273914],"category_scores_gemma":[0.0008479704,0.0002733476,0.00008714371,0.0003357652,0.0003401287,0.00009037477,0.0004029629,0.001450769,0.000162062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227743,"about_ca_system_score_gemma":0.0001303243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004318381,"about_ca_topic_score_gemma":0.00002028307,"domain_scores_codex":[0.9978355,0.0004480044,0.0005329535,0.0006368268,0.00007051684,0.000476256],"domain_scores_gemma":[0.9984182,0.000260199,0.0003183415,0.0007297092,0.0002456013,0.00002794469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005336764,0.0002060445,0.001007698,0.00009503708,0.000287215,0.00003248703,0.0007185787,0.000002063108,0.9886097,0.0002014041,0.001244999,0.007061125],"study_design_scores_gemma":[0.001982801,0.0003343701,0.04726769,0.0001427618,0.00006327536,0.0001864033,0.0001247543,0.000006658106,0.939212,0.0001701794,0.01025199,0.0002571549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9157233,0.07996993,0.0001164332,0.0005932322,0.00209949,0.0006830076,0.00004425736,0.0001061281,0.0006642194],"genre_scores_gemma":[0.9940138,0.0007148251,0.0004122305,0.0002273796,0.00003363325,0.00007397264,0.0003831387,0.00004165092,0.004099348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0792551,"threshold_uncertainty_score":0.9999719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005004564958577413,"score_gpt":0.2571558628479707,"score_spread":0.2521512978893932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}