{"id":"W3162771321","doi":"10.1101/2020.08.20.260190","title":"Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 <i>in vitro</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity","keywords":"Vero cell; Cytopathic effect; In vitro; Virus; Virology; Microbiology; In vivo; Cell culture; Infectivity; Infectious dose; Sodium; Cytotoxicity; Chemistry; Viral replication; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792914,0.0003355628,0.0002238385,0.0001195993,0.0001175307,0.0001629979,0.0001716131,0.0002096659,0.0009169792],"category_scores_gemma":[0.00017141,0.00007511579,0.0002594906,0.0001124429,0.0001253571,0.0001202704,0.00009057504,0.0002478794,0.0003001375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878415,"about_ca_system_score_gemma":0.0001949915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531238,"about_ca_topic_score_gemma":0.001376847,"domain_scores_codex":[0.9998726,0.00003422153,0.00001410061,0.00001658039,0.00004110259,0.00002143304],"domain_scores_gemma":[0.9999269,0.0000169646,0.00001504135,0.000007003322,0.00002424972,0.000009851751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005701187,0.00001465759,0.0000510961,0.00002665742,0.000002458507,0.0000144936,0.000007935386,0.00005574619,0.998925,0.00001479085,0.00003530245,0.0007947568],"study_design_scores_gemma":[0.000006496248,0.0005810147,0.0007012961,0.00000259744,0.00000763969,0.00004653202,0.000008203275,0.0003670851,0.9976801,0.000004216881,0.0005926575,0.000002076189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923649,0.002028447,0.002453145,0.00007440781,0.00003849267,0.00004742335,0.0003352572,0.0000668867,0.002591138],"genre_scores_gemma":[0.9936249,0.0009389018,0.002489328,0.00003881839,0.00001002262,0.00001753038,0.0004429229,0.00001075432,0.002426805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531238,"threshold_uncertainty_score":0.003067613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678399529338551,"score_gpt":0.2372607821640172,"score_spread":0.2204767868706317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}