{"id":"W3162851360","doi":"10.1002/alz.12353","title":"Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Biomarker; Cerebrospinal fluid; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Disease; Oncology; Internal medicine; Cognitive decline; Medicine; Cognitive impairment; Neuroscience; Biology; Dementia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005191529,0.0002904827,0.0002512141,0.000486772,0.0002305324,0.0004394102,0.0001903639,0.0003596262,0.0006018511],"category_scores_gemma":[0.001115892,0.000107545,0.0001043906,0.0003267101,0.000150289,0.0002845741,0.0002032763,0.0002620539,0.0001485644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362987,"about_ca_system_score_gemma":0.0002876055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311845,"about_ca_topic_score_gemma":0.001482569,"domain_scores_codex":[0.999909,0.00001666699,0.000009889708,0.00002611051,0.00002531852,0.00001303492],"domain_scores_gemma":[0.9995323,0.00007055791,0.000182813,0.00002720089,0.0001081652,0.00007890182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001733812,0.000131257,0.9164668,0.00003539472,0.00006305051,0.0003181891,0.0001019836,0.0001630497,0.06878097,0.00003730841,0.0002620019,0.01190619],"study_design_scores_gemma":[0.00002773777,0.0008629996,0.9837883,0.00001279593,0.00006994255,0.001402327,0.0001157394,0.00116004,0.01204378,0.0001258939,0.0003819233,0.000008574154],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990935,0.0003372512,0.0002315033,0.00004085181,0.000004492343,0.000006431959,0.0001130986,0.000008818048,0.0001639755],"genre_scores_gemma":[0.9989202,0.0001306006,0.0005267331,0.00001769195,0.00001029073,0.000007035123,0.0001931658,0.000001271135,0.000193093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311845,"threshold_uncertainty_score":0.002745569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02522915023725881,"score_gpt":0.2773696417851302,"score_spread":0.2521404915478714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}