{"id":"W3162881235","doi":"10.1093/protein/gzab012","title":"High-efficacy, high-manufacturability human VH domain antibody therapeutics from transgenic sources","year":2021,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Antibody; Computational biology; Phage display; Drug discovery; Chemistry; Single-domain antibody; Heavy chain; Recombinant DNA; Combinatorial chemistry; Biochemistry; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004237232,0.0005774043,0.001605167,0.0002317784,0.0002126957,0.0001010973,0.0001418879,0.0004825352,0.0001572498],"category_scores_gemma":[0.00003315908,0.0004520958,0.0003741997,0.0003718653,0.00007276738,0.00005884877,0.00004100613,0.001067781,0.00001449634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425018,"about_ca_system_score_gemma":0.0001848351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000337884,"about_ca_topic_score_gemma":0.000005691649,"domain_scores_codex":[0.9975356,0.0003192957,0.0005727577,0.000684541,0.0004232818,0.0004644645],"domain_scores_gemma":[0.9990644,0.0002916764,0.0001175301,0.0002392565,0.0000873885,0.0001997649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003311417,0.0006664354,0.00002201762,0.02548708,0.003391542,0.0001044631,0.000342369,0.0003542063,0.06309036,0.00136325,0.00007240805,0.9047747],"study_design_scores_gemma":[0.001482738,0.001293026,0.0005374985,0.01176282,0.001784698,0.0001588106,0.00001115951,0.0006851647,0.01017182,0.0003999833,0.9704683,0.001243906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02726857,0.9401945,0.02985146,0.0001260621,0.0001172859,0.002214303,0.00003306738,0.0001892168,0.0000054597],"genre_scores_gemma":[0.006405625,0.9788326,0.0125096,0.00002393226,0.0007002796,0.0002266827,0.0006695834,0.0001194094,0.000512288],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.970396,"threshold_uncertainty_score":0.9997931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05505013346639926,"score_gpt":0.3396046057436717,"score_spread":0.2845544722772724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}