{"id":"W3162881235","doi":"10.1093/protein/gzab012","title":"High-efficacy, high-manufacturability human VH domain antibody therapeutics from transgenic sources","year":2021,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Antibody; Computational biology; Phage display; Drug discovery; Chemistry; Single-domain antibody; Heavy chain; Recombinant DNA; Combinatorial chemistry; Biochemistry; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004944786,0.0006920703,0.0008109945,0.001423569,0.0001730387,0.0008068763,0.0006294298,0.0007357267,0.004055274],"category_scores_gemma":[0.0004150215,0.0002550684,0.0004188931,0.001065122,0.0003204461,0.0009548923,0.0004543781,0.001634824,0.002707872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004692933,"about_ca_system_score_gemma":0.0005668336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004756369,"about_ca_topic_score_gemma":0.0008556613,"domain_scores_codex":[0.9998386,0.00001854609,0.000014623,0.00002700834,0.00008210004,0.00001903212],"domain_scores_gemma":[0.9998523,0.00005566146,0.00002452352,0.000006894506,0.00004643416,0.00001402766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006605812,0.000102916,0.0001023497,0.01483759,0.00007632172,0.0001417931,0.00004171076,0.0006105106,0.01329763,0.009616907,0.02627821,0.9348281],"study_design_scores_gemma":[0.0000132691,0.0001056173,0.0003643571,0.001032851,0.00004736101,0.0004334381,0.00002076058,0.0001070261,0.002738346,0.00127852,0.9938459,0.00001260808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007047147,0.9916643,0.001214325,0.000320292,0.0002982155,0.00002251855,0.0000824801,0.00004237242,0.005650841],"genre_scores_gemma":[0.002939465,0.9931659,0.00081257,0.0002594619,0.0001128457,0.00002549527,0.000127249,0.000005532976,0.002551595],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004055274,"threshold_uncertainty_score":0.0135662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05505013346639926,"score_gpt":0.3396046057436717,"score_spread":0.2845544722772724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}