{"id":"W3162933317","doi":"10.1016/j.chom.2021.04.014","title":"Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Government of South Australia; Uniformed Services University of the Health Sciences; U.S. Army; Gilead Sciences; Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; National Institutes of Health; American Foundation for Aging Research; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Antibody-dependent cell-mediated cytotoxicity; Effector; Biology; Glycoprotein; Epitope; Antibody; Virology; Human immunodeficiency virus (HIV); Viral envelope; Viral replication; Immunology; Virus; Cell; Cell biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002714959,0.0002038555,0.0002117971,0.00007321926,0.0004869382,0.00005536179,0.0003147567,0.0001451375,0.003403472],"category_scores_gemma":[0.0002960949,0.0001499943,0.00009934007,0.0002576376,0.0001059802,0.0001315563,0.0003219992,0.0003174479,0.02598771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032761,"about_ca_system_score_gemma":0.0003456585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547396,"about_ca_topic_score_gemma":0.00007596601,"domain_scores_codex":[0.9984677,0.0002589935,0.000305653,0.0003323342,0.00006196863,0.0005733639],"domain_scores_gemma":[0.9988925,0.0001425761,0.00007681776,0.0005733556,0.0001794532,0.0001352425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001362667,0.0001637903,0.000778134,0.00003515778,0.00007782406,0.00006486098,0.001517195,0.00003989723,0.9306341,0.00008396543,0.06330529,0.00316349],"study_design_scores_gemma":[0.00116439,0.00006759365,0.001852577,0.00003831155,0.00001805588,0.00006782276,0.0006374263,0.000006824018,0.5762231,0.00001681499,0.4197574,0.0001496155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729494,0.004588043,0.0009370379,0.005043417,0.0002445805,0.0008708963,0.0004906812,0.00008754739,0.01478836],"genre_scores_gemma":[0.9570541,0.0001021774,0.0009483712,0.0009869561,0.00004385929,0.000105362,0.002051508,0.00002565963,0.03868197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3564521,"threshold_uncertainty_score":0.9975076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317631173339576,"score_gpt":0.2439331746567921,"score_spread":0.2307568629233963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}