{"id":"W3162933317","doi":"10.1016/j.chom.2021.04.014","title":"Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Government of South Australia; Uniformed Services University of the Health Sciences; U.S. Army; Gilead Sciences; Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; National Institutes of Health; American Foundation for Aging Research; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Antibody-dependent cell-mediated cytotoxicity; Effector; Biology; Glycoprotein; Epitope; Antibody; Virology; Human immunodeficiency virus (HIV); Viral envelope; Viral replication; Immunology; Virus; Cell; Cell biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353742,0.0002277128,0.0001985508,0.00009489517,0.0001401955,0.0004680458,0.0002503965,0.0002632825,0.002899081],"category_scores_gemma":[0.0002627677,0.0001219081,0.0001298585,0.00007033035,0.0001813721,0.0002957851,0.0001551054,0.0006992599,0.0004182423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165213,"about_ca_system_score_gemma":0.0001606749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001864907,"about_ca_topic_score_gemma":0.0003256391,"domain_scores_codex":[0.9999197,0.000017446,0.00000465451,0.00001331033,0.00001531714,0.0000296197],"domain_scores_gemma":[0.9999343,0.00001695679,0.0000162396,0.000008341797,0.000007914237,0.00001631492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004037796,0.0002203451,0.0002316608,0.00003172096,0.000008141636,0.00002055642,0.00001595164,0.000454981,0.9920174,0.0002987319,0.0001322,0.006164618],"study_design_scores_gemma":[0.0001699737,0.002097379,0.002055973,0.00001776448,0.00004068494,0.0002339462,0.00004288086,0.004449301,0.987643,0.000354913,0.002879895,0.00001422724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951933,0.001213139,0.001550812,0.0002059936,0.00006299391,0.0000346049,0.00005858177,0.0000562052,0.00162439],"genre_scores_gemma":[0.9969171,0.000547366,0.001227618,0.0001130506,0.00001670449,0.00001488186,0.00004685668,0.00001653517,0.001099882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002899081,"threshold_uncertainty_score":0.009698391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317631173339576,"score_gpt":0.2439331746567921,"score_spread":0.2307568629233963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}