{"id":"W3162935255","doi":"10.1016/j.msard.2021.103006","title":"Interleukin-1 receptor antagonist: An exploratory plasma biomarker that correlates with disability and provides pathophysiological insights in relapsing-remitting multiple sclerosis","year":2021,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Horizon Health Network; University of British Columbia; Memorial University of Newfoundland","funders":"Multiple Sclerosis Society of Canada","keywords":"Multiple sclerosis; Medicine; Biomarker; Interleukin 1 receptor antagonist; Microglia; Receptor antagonist; Expanded Disability Status Scale; Immunology; Cerebrospinal fluid; Interleukin; Pathology; Internal medicine; Receptor; Antagonist; Inflammation; Cytokine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008230272,0.0005309507,0.0005949881,0.0008778672,0.0003850668,0.0008095557,0.0001996659,0.0007355249,0.0006938583],"category_scores_gemma":[0.002126369,0.0001675105,0.0002386707,0.0006861423,0.0002262201,0.000461037,0.0003156701,0.0005533068,0.0002252586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001601782,"about_ca_system_score_gemma":0.0003470261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004631386,"about_ca_topic_score_gemma":0.0007356685,"domain_scores_codex":[0.9995552,0.0001938196,0.00004272303,0.00007554995,0.00008447437,0.00004820964],"domain_scores_gemma":[0.9990972,0.0002468108,0.0003562453,0.00005001575,0.0001117193,0.0001380033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004303963,0.0004934669,0.9269928,0.0002007032,0.00056631,0.0007963996,0.000418135,0.0002427059,0.04015292,0.0001375467,0.0004949766,0.02520005],"study_design_scores_gemma":[0.000124986,0.002308484,0.9884133,0.00004428575,0.0002919767,0.00271387,0.0002826704,0.0007925181,0.003885934,0.0002085299,0.000909121,0.00002435632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965803,0.001781869,0.0003927476,0.00008976199,0.00002032332,0.00003013117,0.0002667709,0.00002025104,0.000817895],"genre_scores_gemma":[0.9981067,0.0003926213,0.0008006661,0.00009864161,0.00005056672,0.00003136826,0.0002627207,0.000003653928,0.0002531279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008778672,"threshold_uncertainty_score":0.004352629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859214145914149,"score_gpt":0.259941494410285,"score_spread":0.2013493529511435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}