{"id":"W3162982128","doi":"10.1158/0008-5472.can-20-3694","title":"SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Beatson Institute for Cancer Research; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester; Ligue Contre le Cancer; European Commission; Cancer Research UK","keywords":"Prostate cancer; Androgen deprivation therapy; mTORC1; Cancer research; Androgen receptor; Amino acid transporter; PI3K/AKT/mTOR pathway; Regulator; Prostate; Cancer; Androgen; Medicine; Transporter; Internal medicine; Biology; Signal transduction; Hormone; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000080686,0.0002704219,0.0001412568,0.0002324788,0.0001738451,0.0002431587,0.0001171026,0.0001690762,0.001065492],"category_scores_gemma":[0.00005794957,0.00007442758,0.0002809158,0.0001409847,0.0001542433,0.000106512,0.0001474128,0.0002577018,0.0002274808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665832,"about_ca_system_score_gemma":0.0002078853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002058495,"about_ca_topic_score_gemma":0.002765332,"domain_scores_codex":[0.9999259,0.00001059276,0.000005530322,0.00001495534,0.00002362638,0.00001949203],"domain_scores_gemma":[0.999959,0.00000337668,0.00001551817,0.000003350345,0.000004969052,0.00001374838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001933836,0.00002527653,0.001034858,0.00005325947,0.000008454263,0.00005157799,0.00001049972,0.0001577191,0.996971,0.00006019581,0.0001294107,0.001304267],"study_design_scores_gemma":[0.00004282063,0.0007885995,0.05896278,0.00001875171,0.00004637439,0.0008979623,0.0001126412,0.004881857,0.9287364,0.00007222541,0.005424847,0.00001475291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959295,0.001602067,0.0008600949,0.00007352639,0.0000211365,0.00001476758,0.0006878928,0.00006432553,0.0007465706],"genre_scores_gemma":[0.9978968,0.0003102807,0.0004071136,0.00003817196,0.000002970802,0.000009091373,0.000659027,0.000006546023,0.0006699264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058495,"threshold_uncertainty_score":0.004093051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09149100848381074,"score_gpt":0.4304945983274098,"score_spread":0.3390035898435991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}