{"id":"W3162995210","doi":"10.3390/cells10051170","title":"Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Myeloid-derived Suppressor Cell; Immunotherapy; Cancer immunotherapy; Immunology; Suppressor; Myeloid cells; Myeloid; Cancer; Immunity; Medicine; Immune system; Cancer research; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047706,0.0007295538,0.0008929099,0.001585949,0.0002357444,0.00077128,0.0005442939,0.0007573687,0.003002156],"category_scores_gemma":[0.0004054609,0.0001966606,0.0003527791,0.00136525,0.0003921216,0.0009620448,0.0006573491,0.001679122,0.001754255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005045513,"about_ca_system_score_gemma":0.0007352739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004844571,"about_ca_topic_score_gemma":0.0009420462,"domain_scores_codex":[0.9998683,0.00002559985,0.00001574705,0.0000166174,0.00005791159,0.00001586448],"domain_scores_gemma":[0.9998544,0.00006323973,0.0000204125,0.000005205096,0.00003625358,0.0000204624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007356252,0.00007678667,0.0001351598,0.01339053,0.00005106414,0.0001865904,0.00006972742,0.0004422153,0.004399082,0.00545004,0.03811724,0.937608],"study_design_scores_gemma":[0.000009608601,0.00007136819,0.0004469925,0.002159589,0.00003576718,0.0009035566,0.00003261721,0.00005301945,0.0005311244,0.002027142,0.9937187,0.00001044921],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009427105,0.9984928,0.0001023028,0.000167769,0.000268021,0.000003099095,0.000009515801,0.000006150593,0.0008560955],"genre_scores_gemma":[0.0005794452,0.9982541,0.0001254401,0.0001328807,0.0002370013,0.000004887523,0.00001931295,0.000001227955,0.0006456353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003002156,"threshold_uncertainty_score":0.01004326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502673492513295,"score_gpt":0.2915552619193932,"score_spread":0.2765285269942602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}