{"id":"W3162998638","doi":"10.1128/aac.00491-21","title":"Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Virology; NOD2; Antiviral drug; Biology; Coronavirus; Zika virus; Broad spectrum; Viral replication; Coronaviridae; Virus; Interferon; Immunology; Innate immune system; Infectious disease (medical specialty); Immune system; Medicine; Chemistry; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031874,0.0003311406,0.0003122024,0.0001925882,0.0001363734,0.0002549036,0.0001913804,0.0002235483,0.0008756525],"category_scores_gemma":[0.0000329528,0.00008613098,0.0002270261,0.00006142104,0.0001526855,0.0002565161,0.0002183451,0.000436257,0.0001781345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722526,"about_ca_system_score_gemma":0.0001756775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000222856,"about_ca_topic_score_gemma":0.000961983,"domain_scores_codex":[0.9999468,0.00001227286,0.000004311219,0.00001098876,0.00001083654,0.00001471656],"domain_scores_gemma":[0.9999821,0.000002305463,0.000003704228,0.000001788641,0.000003164625,0.000006828014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003600162,0.0001941788,0.0001564134,0.0001497021,0.00001767752,0.0001830675,0.00002293477,0.0003537205,0.9788036,0.0005286488,0.0002444614,0.01898562],"study_design_scores_gemma":[0.0003490123,0.004368432,0.002469364,0.00002869324,0.0000680407,0.001144034,0.00004297559,0.002651098,0.9679502,0.0001883487,0.02071473,0.00002497195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573276,0.0197021,0.01262528,0.0006555842,0.0002646272,0.0003192498,0.0003489989,0.000216961,0.008539652],"genre_scores_gemma":[0.979903,0.007579931,0.006902959,0.0002265974,0.00003266886,0.0001164594,0.0003280294,0.00001403525,0.004896186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008756525,"threshold_uncertainty_score":0.00292933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020119159497144,"score_gpt":0.2799680816252966,"score_spread":0.2598489221281526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}