{"id":"W3163013904","doi":"10.2139/ssrn.3824765","title":"A First-in-Human Phase I/IIa Study of Allogeneic Double Negative T Cell for the Treatment of Relapsed AML Post Allo-HSCT","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Complete remission; Internal medicine; Hematopoietic stem cell transplantation; Myeloid leukemia; CD8; Gastroenterology; Transplantation; Disease; Minimal residual disease; Chemotherapy; Oncology; Leukemia; Surgery; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002558046,0.002100955,0.002973456,0.0007279328,0.001040223,0.001884995,0.001494809,0.002293285,0.004244835],"category_scores_gemma":[0.001001954,0.0007564581,0.002010976,0.000556202,0.001821271,0.001074105,0.0005372915,0.005836498,0.001540742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138938,"about_ca_system_score_gemma":0.002770919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002345251,"about_ca_topic_score_gemma":0.004623558,"domain_scores_codex":[0.9991943,0.0003560279,0.00003295137,0.0001221126,0.00004762201,0.0002469292],"domain_scores_gemma":[0.9989071,0.0001461454,0.0001040878,0.0001498699,0.00005140491,0.0006413213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5939924,0.2250354,0.004819463,0.0009325575,0.001404763,0.0009768553,0.0007840982,0.004401892,0.07532665,0.0009384289,0.005764777,0.08562279],"study_design_scores_gemma":[0.2990764,0.6864181,0.004290583,0.00003679239,0.0003655117,0.0003228615,0.0001210261,0.0006403566,0.005490906,0.0003067839,0.002897407,0.00003330798],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874626,0.001592369,0.001199556,0.0007620086,0.0002617522,0.004434234,0.001983884,0.0001126105,0.002190886],"genre_scores_gemma":[0.9802556,0.002280032,0.002420365,0.001821631,0.0002930647,0.004194826,0.003310122,0.00008176745,0.005342503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004244835,"threshold_uncertainty_score":0.01420039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944540295255782,"score_gpt":0.3511902579164156,"score_spread":0.3217448549638578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}