{"id":"W3163021674","doi":"10.1186/s12964-021-00706-1","title":"Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism","year":2021,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"mTORC1; AMPK; Nutrient sensing; PI3K/AKT/mTOR pathway; Autophagy; Biology; Transcription factor; Mechanistic target of rapamycin; Cell biology; mTORC2; NAD+ kinase; Signal transduction; Protein kinase A; Kinase; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658248,0.00009879895,0.0002111109,0.00005705605,0.0002535376,0.00004353657,0.00004522112,0.00005192916,0.00002410592],"category_scores_gemma":[0.00002858403,0.00008839461,0.00003421648,0.00006765151,0.0001178716,0.00007593146,0.00006866782,0.0001634512,2.023447e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121452,"about_ca_system_score_gemma":0.0000534522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002270023,"about_ca_topic_score_gemma":0.00001279798,"domain_scores_codex":[0.9993669,0.00005631222,0.00020494,0.0001765633,0.0000940165,0.0001013149],"domain_scores_gemma":[0.9991248,0.000298923,0.00007631593,0.0002099364,0.0001774015,0.0001126581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0007344118,0.001972987,0.02759958,0.002085726,0.0006279914,0.00004484956,0.02152037,0.06013259,0.7951204,0.04993645,0.00928177,0.03094286],"study_design_scores_gemma":[0.002161188,0.00002713164,0.002265503,0.0001042851,0.000124661,0.00002648389,0.0007847793,0.9845557,0.003125418,0.001393241,0.005323682,0.0001078834],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8527614,0.02456252,0.1176803,0.001738607,0.00006890375,0.0001984183,0.00001271845,0.0000357457,0.002941328],"genre_scores_gemma":[0.9615623,0.002466951,0.03315951,0.000876828,0.00004667058,0.00002312433,0.0001387603,0.00001352469,0.001712331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9244232,"threshold_uncertainty_score":0.3604628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965590459872736,"score_gpt":0.26937614813747,"score_spread":0.2497202435387426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}