{"id":"W3163101987","doi":"10.1101/2021.05.17.444252","title":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in <i>Drosophila melanogaster</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Core Research for Evolutional Science and Technology; Institute of Genetics; University of Tsukuba; Japan Agency for Medical Research and Development","keywords":"Incretin; Internal medicine; Glucagon; Endocrinology; Hormone; Insulin; Biology; Drosophila melanogaster; Enteroendocrine cell; Neuropeptide; Receptor; Endocrine system; Diabetes mellitus; Biochemistry; Type 2 diabetes; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004933312,0.0001840989,0.0001107387,0.0001471625,0.0001224939,0.0002333878,0.000126984,0.0001826144,0.0007740312],"category_scores_gemma":[0.00004503261,0.00009174938,0.0001701683,0.00005458886,0.0001399878,0.0001323194,0.0001699311,0.0002485531,0.0002461953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670337,"about_ca_system_score_gemma":0.0001216756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001782758,"about_ca_topic_score_gemma":0.003076616,"domain_scores_codex":[0.9999683,0.000003712735,0.000002736352,0.00001009482,0.000007990613,0.000007203444],"domain_scores_gemma":[0.9999673,0.000003358738,0.00001090289,0.000002986068,0.000003983595,0.00001158332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005788175,0.000003553401,0.0006047927,0.00002013081,0.000003398902,0.0001090643,0.00001168122,0.00003997478,0.9981233,0.00008903316,0.00009040644,0.0008467602],"study_design_scores_gemma":[0.00003913102,0.0001309876,0.06914829,0.00002167826,0.00002588312,0.0005899763,0.0001416238,0.002521714,0.9190117,0.0001332962,0.008217749,0.00001807261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922717,0.001431044,0.001928698,0.0001468841,0.00003095247,0.0000141344,0.0007887017,0.00008240808,0.003305399],"genre_scores_gemma":[0.9906347,0.0006982883,0.001882629,0.0001270127,0.000006971337,0.0000182502,0.0007732265,0.00003768619,0.005821181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782758,"threshold_uncertainty_score":0.003544807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993113649827498,"score_gpt":0.246212222268014,"score_spread":0.226281085769739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}