{"id":"W3163107759","doi":"10.1038/s42003-021-02126-w","title":"Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UK Dementia Research Institute; University of Toronto; Medical Research Council; Royal Society; Parkinson's UK; Alzheimer's Society","keywords":"Protein aggregation; Biophysics; Seeding; Chemistry; Fibril; Synucleinopathies; Cell biology; SH-SY5Y; Amyloid (mycology); Mechanism (biology); Endogeny; Nanoscopic scale; Alpha-synuclein; Cell culture; Nanotechnology; Biology; Biochemistry; Parkinson's disease; Materials science; Disease; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175743,0.0001131362,0.0002237626,0.0001379177,0.0001381153,0.00001323908,0.0002009768,0.00008837637,0.0001274747],"category_scores_gemma":[0.0001362013,0.0001122537,0.00007186516,0.0003075447,0.0001013948,0.0000619216,0.0002074025,0.0001580044,0.0001195184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568288,"about_ca_system_score_gemma":0.0001191846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001057931,"about_ca_topic_score_gemma":0.0001232633,"domain_scores_codex":[0.9989647,0.0002568987,0.0002671692,0.0002454082,0.00005681074,0.0002090049],"domain_scores_gemma":[0.998367,0.0001280218,0.00006944038,0.001224629,0.0001291718,0.00008171642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001044865,0.001992265,0.2236836,0.00005656335,0.0001684878,0.0001062433,0.0005736577,0.000009349149,0.6872501,0.02149129,0.00121404,0.06334995],"study_design_scores_gemma":[0.01272318,0.0003729831,0.451073,0.0008931779,0.0006987019,0.0003848575,0.002432144,0.02745994,0.132647,0.02766899,0.3425823,0.001063717],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709929,0.01159522,0.0007224096,0.009233048,0.0001728014,0.0004418816,0.00006750314,0.0001014737,0.006672809],"genre_scores_gemma":[0.9885635,0.001660941,0.007804498,0.0006278953,0.00002263443,0.00007871741,0.0007797701,0.0000141429,0.0004478731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.554603,"threshold_uncertainty_score":0.4577571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03753797073225944,"score_gpt":0.3187195857004372,"score_spread":0.2811816149681777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}