{"id":"W3163157599","doi":"10.3389/fnagi.2021.619916","title":"Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jiangsu Provincial Medical Youth Talent; Southeast University; National Natural Science Foundation of China","keywords":"Type 2 diabetes; Cognitive impairment; SNP; Polymorphism (computer science); Internal medicine; Medicine; Single-nucleotide polymorphism; Diabetes mellitus; Endocrinology; Genetics; Biology; Genotype; Disease; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000206877,0.0001856079,0.0005272148,0.0002902172,0.00003497919,0.00001531569,0.0001016712,0.00005590707,0.000002028718],"category_scores_gemma":[0.0003122584,0.0001492752,0.00002611874,0.000935543,0.0003652059,0.0001528936,0.00006757959,0.0002239232,1.391213e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004778417,"about_ca_system_score_gemma":0.0001362135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004741256,"about_ca_topic_score_gemma":0.00004329884,"domain_scores_codex":[0.9983603,0.0001121205,0.000308213,0.0004404192,0.0004559074,0.0003230363],"domain_scores_gemma":[0.9992008,0.00006085704,0.000250036,0.0001965992,0.0001721928,0.0001195415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003195376,0.0005734981,0.9944547,0.00006711144,0.00001550794,0.00003065692,0.0005220961,0.00001716996,0.00341104,6.75873e-7,0.00004349726,0.0005444381],"study_design_scores_gemma":[0.007427686,0.0005282931,0.9789733,0.001591643,0.00006284217,0.000003323257,0.0002509877,0.0006316786,0.0103739,0.000004589409,0.00001176361,0.0001399898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989235,0.0001828897,0.00004643505,0.0001018526,0.0002994681,0.0003310535,0.00007230318,0.00001199689,0.00003054911],"genre_scores_gemma":[0.9989322,0.00002587389,0.0003807599,0.000528138,0.00001110541,0.000008529539,0.00001780546,0.00001923223,0.00007629236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01548147,"threshold_uncertainty_score":0.6087265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472827284732928,"score_gpt":0.2402645171631401,"score_spread":0.2155362443158108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}