{"id":"W3163188754","doi":"10.1016/j.str.2021.04.011","title":"Bipartite binding of the N terminus of Skp2 to cyclin A","year":2021,"lang":"en","type":"article","venue":"Structure","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Institute of Cancer Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cyclin-dependent kinase; Cyclin A; Cyclin-dependent kinase complex; Cyclin A2; Cyclin D; Cyclin-dependent kinase 2; Cyclin E; Cyclin B; Cell biology; SKP2; Chemistry; Cyclin; Biology; Ubiquitin; Cancer research; Cell cycle; Biochemistry; Kinase; Ubiquitin ligase; Protein kinase A; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003262527,0.00007549267,0.0001958915,0.00004882783,0.00001964263,0.000002869744,0.0000779102,0.00008240865,0.0002292862],"category_scores_gemma":[0.0001650512,0.00005231777,0.0001019709,0.000416454,0.0000403519,0.00001031062,0.00007198769,0.0001563966,0.000003105758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003173714,"about_ca_system_score_gemma":0.0001668433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001482126,"about_ca_topic_score_gemma":0.0000537285,"domain_scores_codex":[0.999337,0.00002341627,0.00018105,0.0001414322,0.0001999151,0.0001171675],"domain_scores_gemma":[0.9993569,0.00001324665,0.000077196,0.0004091804,0.00008845191,0.000055071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003053907,0.000009994436,0.002537783,0.00008710629,0.00004489935,0.00004252611,0.0004739932,0.00006048803,0.9929128,0.0001143018,0.0008954323,0.002790095],"study_design_scores_gemma":[0.0004989136,0.0000528458,0.02061563,0.0002316267,0.00007069443,0.0001399021,0.000085259,0.00001298931,0.9702282,0.0001491636,0.007861309,0.00005347294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973139,0.0002550313,0.00003290791,0.0006779771,0.0004402266,0.000169004,0.00009600137,0.000009597074,0.001005389],"genre_scores_gemma":[0.9982668,0.000004682664,0.0007929558,0.0002426302,0.00008171157,0.000001830985,0.000008063646,0.00001382924,0.0005874669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02268465,"threshold_uncertainty_score":0.2510523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007540755910510423,"score_gpt":0.2547836243594987,"score_spread":0.2472428684489883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}