{"id":"W3163188754","doi":"10.1016/j.str.2021.04.011","title":"Bipartite binding of the N terminus of Skp2 to cyclin A","year":2021,"lang":"en","type":"article","venue":"Structure","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Institute of Cancer Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cyclin-dependent kinase; Cyclin A; Cyclin-dependent kinase complex; Cyclin A2; Cyclin D; Cyclin-dependent kinase 2; Cyclin E; Cyclin B; Cell biology; SKP2; Chemistry; Cyclin; Biology; Ubiquitin; Cancer research; Cell cycle; Biochemistry; Kinase; Ubiquitin ligase; Protein kinase A; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834148,0.0003097281,0.0002301948,0.0002422954,0.000719666,0.0004766665,0.0003456963,0.0004170935,0.004228663],"category_scores_gemma":[0.0003186976,0.0002152484,0.0004253539,0.0001712618,0.0002893567,0.0003538405,0.0006045763,0.000693855,0.001373677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009728989,"about_ca_system_score_gemma":0.0008243163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001563897,"about_ca_topic_score_gemma":0.00362729,"domain_scores_codex":[0.9998628,0.00002237664,0.000007646224,0.00004206206,0.00002809022,0.00003702869],"domain_scores_gemma":[0.9998085,0.0000383812,0.00002730838,0.00002572951,0.00002171437,0.0000784089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002816665,0.00002462423,0.0002836651,0.00004973193,0.00001108348,0.0002493752,0.00003122434,0.0002033354,0.9958076,0.00167049,0.0002856787,0.001101509],"study_design_scores_gemma":[0.00008456533,0.0002910946,0.02025234,0.00003448682,0.00003173227,0.001427563,0.000207951,0.007600797,0.9499907,0.001778119,0.01826518,0.00003535813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805288,0.001415454,0.0100353,0.0002816414,0.0001282673,0.00003713597,0.0004270366,0.0001420435,0.007004378],"genre_scores_gemma":[0.9898368,0.0003413394,0.003648664,0.0001833858,0.00001896291,0.00002380343,0.0008723967,0.00002384173,0.005050757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004228663,"threshold_uncertainty_score":0.01414627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007540755910510423,"score_gpt":0.2547836243594987,"score_spread":0.2472428684489883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}