{"id":"W3163189192","doi":"10.3389/fcell.2021.662791","title":"Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Aptamer; Cancer; Immunotherapy; Medicine; Disease; Targeted therapy; Cancer immunotherapy; Pharmacology; Computational biology; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001912386,0.0003420877,0.00103668,0.0002387504,0.00004932698,0.000008109911,0.0001225955,0.0003992237,0.000001226211],"category_scores_gemma":[0.000008732147,0.0002845258,0.00007984247,0.0002051218,0.0002284028,0.000005370869,0.0001983517,0.0001783407,1.640751e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005398729,"about_ca_system_score_gemma":0.0002621923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005946931,"about_ca_topic_score_gemma":0.00006691454,"domain_scores_codex":[0.998351,0.0001192846,0.0005878792,0.0006022148,0.00005868287,0.0002809158],"domain_scores_gemma":[0.9995654,0.00002135311,0.0002292388,0.0001088203,0.00002435169,0.00005081763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000121706,0.00002965989,0.00113466,0.0008280932,0.00006691769,0.000003959505,0.00005414143,3.933461e-7,0.004448303,8.568514e-7,0.0000507266,0.9933701],"study_design_scores_gemma":[0.0002879615,0.00003906228,0.00002137915,0.001697993,0.00004347126,0.000006306956,0.0005092284,0.000003473838,0.03699498,0.00001083794,0.9599135,0.0004718311],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001391993,0.9962772,0.001729156,0.00000294826,0.00013142,0.0002125938,0.00002284459,0.000005962279,0.0002258715],"genre_scores_gemma":[0.001445752,0.9057196,0.09238385,0.00004642509,0.00001888185,0.00003620768,0.0002791149,0.00001935212,0.00005079126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9928983,"threshold_uncertainty_score":0.9999607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940781351498531,"score_gpt":0.3042478196965414,"score_spread":0.2848400061815561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}