{"id":"W3163218484","doi":"10.1038/s41420-021-00491-3","title":"ROS induces NETosis by oxidizing DNA and initiating DNA repair","year":2021,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canadian Institutes of Health Research; Mitacs; Government of Canada","keywords":"Neutrophil extracellular traps; DNA damage; Biology; Cell biology; Chromatin; Molecular biology; DNA repair; Proliferating cell nuclear antigen; Poly ADP ribose polymerase; Polymerase; DNA; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399919,0.0002942286,0.0001756764,0.00015109,0.0001376306,0.0002550463,0.0001144296,0.0002700797,0.001402478],"category_scores_gemma":[0.00009765262,0.00009306274,0.000187561,0.000057085,0.0001740732,0.0002074637,0.000247882,0.0004193066,0.0002804066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586297,"about_ca_system_score_gemma":0.0001383096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001442915,"about_ca_topic_score_gemma":0.000286812,"domain_scores_codex":[0.9998765,0.00002133913,0.00001117552,0.00002343957,0.00004014666,0.00002734967],"domain_scores_gemma":[0.9998903,0.0000154682,0.0000341176,0.00001282146,0.00001712442,0.00003007642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047145,0.00001839794,0.0002008799,0.00004673942,0.000004095625,0.00007191739,0.000008500111,0.00002038551,0.9980782,0.0001430008,0.00003623877,0.00126702],"study_design_scores_gemma":[0.00001253499,0.0002937215,0.003766978,0.00001050781,0.000008476699,0.0003811765,0.00001980218,0.0003210958,0.9925084,0.0001258697,0.002548699,0.000002724899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807,0.005997546,0.009091234,0.0002429571,0.0001279872,0.0000833569,0.0003341085,0.0001331714,0.003289651],"genre_scores_gemma":[0.9920328,0.001911941,0.003067034,0.00008635894,0.00002535162,0.00002720241,0.0002935695,0.00001049681,0.002545449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402478,"threshold_uncertainty_score":0.00469172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652064268693165,"score_gpt":0.223305128460813,"score_spread":0.2067844857738814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}