{"id":"W3163218484","doi":"10.1038/s41420-021-00491-3","title":"ROS induces NETosis by oxidizing DNA and initiating DNA repair","year":2021,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canadian Institutes of Health Research; Mitacs; Government of Canada","keywords":"Neutrophil extracellular traps; DNA damage; Biology; Cell biology; Chromatin; Molecular biology; DNA repair; Proliferating cell nuclear antigen; Poly ADP ribose polymerase; Polymerase; DNA; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001556466,0.000265443,0.0003434467,0.0000621388,0.0003302723,0.0000956657,0.0001319041,0.0002247315,0.0001809993],"category_scores_gemma":[0.00006557132,0.0002463362,0.0001251181,0.0001461883,0.00009406785,0.0004698471,0.0002450591,0.0003135227,0.0001196356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000353839,"about_ca_system_score_gemma":0.00008670428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000360109,"about_ca_topic_score_gemma":0.00000489797,"domain_scores_codex":[0.9984139,0.0002315047,0.0003032969,0.0005644241,0.00004822058,0.0004387079],"domain_scores_gemma":[0.9993008,0.0001744464,0.0001197233,0.0003104235,0.00005294187,0.00004165995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002400953,0.0001022721,0.0006837359,0.00004443126,0.00009328787,0.00005603654,0.0002775345,5.841508e-7,0.9951109,0.00111541,0.001988054,0.0005037304],"study_design_scores_gemma":[0.0006964337,0.00009909116,0.0009890333,0.0000730118,0.0000693583,0.00004772529,0.0008251896,0.000001286217,0.987873,0.00032746,0.008698125,0.0003003347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874548,0.008505206,0.0002108812,0.0001179285,0.0004992594,0.0001313395,0.00008720582,0.0001129269,0.002880397],"genre_scores_gemma":[0.9931378,0.0006516385,0.0003139618,0.0008755373,0.00006679056,0.00002394779,0.0002786104,0.00003463141,0.004617116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007853567,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652064268693165,"score_gpt":0.223305128460813,"score_spread":0.2067844857738814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}