{"id":"W3163226991","doi":"10.1038/s41467-021-23071-6","title":"Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Lake Champlain Cancer Research Organization; National Cancer Institute; National Institutes of Health; University of Vermont; Boettcher Foundation; Anschutz Medical Campus, University of Colorado; Foundation for the National Institutes of Health","keywords":"ATP-binding cassette transporter; Efflux; Context (archaeology); Mitochondrion; In vivo; Cancer cell; Cancer; Transporter; Drug; Cancer research; Pharmacology; Chemistry; Biology; Cell biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593331,0.0001564062,0.0002490867,0.0001578785,0.000126951,0.0004209446,0.0002175359,0.0003880914,0.0009461931],"category_scores_gemma":[0.000149921,0.0001028397,0.0001287801,0.0001460069,0.0002754519,0.0003661493,0.0002289531,0.000459971,0.000210618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080284,"about_ca_system_score_gemma":0.0001781901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294475,"about_ca_topic_score_gemma":0.0005810427,"domain_scores_codex":[0.9999157,0.00001992821,0.000007795743,0.00001312202,0.00002805096,0.0000154408],"domain_scores_gemma":[0.9999247,0.00001270552,0.00003076008,0.000007153055,0.00001055351,0.00001412562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000921272,0.00002613753,0.0006430795,0.00009617426,0.00000732052,0.0001060884,0.00002621697,0.0002663057,0.9918196,0.001035816,0.0001538306,0.005727339],"study_design_scores_gemma":[0.00002578968,0.0004156203,0.006107945,0.00001775538,0.00002256388,0.0006910651,0.00005436669,0.001820357,0.9774525,0.0005701075,0.01281015,0.000011711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969729,0.01783614,0.006876175,0.001132281,0.0001128797,0.00003502906,0.0001564343,0.0001446554,0.003977505],"genre_scores_gemma":[0.9931892,0.00414608,0.001291075,0.0001348076,0.00001556188,0.000008326273,0.00007141634,0.00001012393,0.001133389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009461931,"threshold_uncertainty_score":0.003165305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539281546208518,"score_gpt":0.3004055032789261,"score_spread":0.2850126878168409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}