{"id":"W3163246929","doi":"10.1101/2021.05.21.445166","title":"Cap-dependent translation initiation monitored in living cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"EIF4E; Translation (biology); Eukaryotic translation; Cell biology; Messenger RNA; Initiation factor; Eukaryotic initiation factor; Phosphorylation; Biophysics; Protein biosynthesis; Live cell imaging; Biology; Cytoplasm; Translational regulation; Computational biology; Chemistry; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002801597,0.0002821718,0.0004044188,0.0002319278,0.0003082678,0.000469279,0.00031264,0.0003893234,0.001466852],"category_scores_gemma":[0.0002670277,0.000199406,0.000162212,0.0004113151,0.0003693617,0.0003367929,0.0002795476,0.0008580323,0.0007266925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006813853,"about_ca_system_score_gemma":0.0002765341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149012,"about_ca_topic_score_gemma":0.001078029,"domain_scores_codex":[0.9997439,0.0000363379,0.00001311233,0.0000918614,0.00008310899,0.00003177171],"domain_scores_gemma":[0.999833,0.00006493292,0.0000249861,0.00002575496,0.00003398659,0.00001731349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003853893,0.00001927945,0.00009804968,0.00003048375,0.000003089076,0.00003239169,0.00003984185,0.0001523965,0.9981731,0.0002439618,0.00009417708,0.001074632],"study_design_scores_gemma":[0.000006783268,0.0000470384,0.0007821664,0.000003877356,0.000003777102,0.0000412321,0.00001689266,0.002778884,0.9947191,0.0001023165,0.00149208,0.000005886445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240002,0.002560245,0.06260511,0.0002156324,0.0001767899,0.0001060565,0.00163842,0.0007609011,0.007936632],"genre_scores_gemma":[0.9408684,0.002082331,0.04827105,0.0001256821,0.00006123351,0.0002832278,0.001683681,0.0001845781,0.006439803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466852,"threshold_uncertainty_score":0.004943848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082631546856044,"score_gpt":0.2721506190523557,"score_spread":0.2413243035837952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}