{"id":"W3163431319","doi":"10.1016/s1465324921005934","title":"A novel high-permeability fep bag for gmp-compliant, scalable expansion of t cells in a fully closed system","year":2021,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint-Gobain (Canada)","funders":"","keywords":"Cyclic gmp; Scalability; Computer science; Chemistry; Biochemistry; Operating system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007828292,0.0002287368,0.0007784527,0.0001835527,0.00005811948,0.00002499537,0.000176615,0.0001916527,0.001355671],"category_scores_gemma":[0.00006510599,0.0002072988,0.0002427681,0.0005757446,0.0001178643,0.00006376144,0.00003657117,0.0002339512,0.00002083543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945346,"about_ca_system_score_gemma":0.000526187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003326058,"about_ca_topic_score_gemma":0.00008337288,"domain_scores_codex":[0.9977331,0.0001236915,0.0005805074,0.0005826853,0.0004826811,0.0004973809],"domain_scores_gemma":[0.9981267,0.0003069567,0.0001092499,0.0008774616,0.000419962,0.000159673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00218839,0.0006840566,0.001537185,0.0009858616,0.00008182266,0.00004225546,0.0004343711,0.00004342708,0.9840203,0.0003085854,0.0003040367,0.009369687],"study_design_scores_gemma":[0.01251987,0.0007217134,0.009692381,0.0005549946,0.00002586398,0.00006711549,0.0005620918,0.00247369,0.9672657,0.0001156466,0.005777297,0.0002235941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925703,0.0005147404,0.003214337,0.0005253823,0.0002343935,0.001713219,0.0001013971,0.00006754488,0.001058641],"genre_scores_gemma":[0.9855203,0.0001328083,0.008637608,0.0002777728,0.0001915202,0.0001980161,0.00004421159,0.00008457852,0.004913204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01675458,"threshold_uncertainty_score":0.9995572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856647636727194,"score_gpt":0.3109121678063043,"score_spread":0.2723456914390324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}