{"id":"W3163452526","doi":"10.3390/biology10050433","title":"An “Omic” Overview of Fragile X Syndrome","year":2021,"lang":"en","type":"review","venue":"Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Sherbrooke","funders":"","keywords":"Fragile X syndrome; FMR1; Biology; Fragile x; Gene silencing; Neuroscience; Phenotype; Regulator; Bioinformatics; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009486202,0.0002962249,0.0009811975,0.00006076854,0.00002741799,0.000006934361,0.0003805887,0.0005118262,0.0001111717],"category_scores_gemma":[0.00002706385,0.0002609557,0.0003345017,0.0001155142,0.00009016174,8.035137e-7,0.0002096657,0.0001068987,0.00001978619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008364374,"about_ca_system_score_gemma":0.0002690482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007058185,"about_ca_topic_score_gemma":0.000006855142,"domain_scores_codex":[0.9985169,0.0002151978,0.0004270723,0.0005574476,0.00004981889,0.0002336033],"domain_scores_gemma":[0.9990913,0.00001202641,0.0002127034,0.0005655412,0.00004566735,0.00007272057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000506976,0.0002299456,0.000042392,0.004857371,0.000401098,0.00002025639,0.000009911586,0.000001458158,0.008757095,0.000412593,0.002022247,0.9832405],"study_design_scores_gemma":[0.00009295385,0.0003226309,0.00005481391,0.0005505111,0.00009930928,0.00008364304,0.000004620517,2.822774e-7,0.0002428829,0.0000206485,0.9982546,0.000273093],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001834479,0.9971941,0.00002314058,0.000006359977,0.0002845157,0.0002214182,0.0001959696,0.000005691414,0.0002343447],"genre_scores_gemma":[0.001136838,0.9952877,0.000266556,0.000105113,0.0000278502,0.00003980348,0.002956752,0.00004501582,0.0001344427],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962324,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05853774593256662,"score_gpt":0.3578456953029588,"score_spread":0.2993079493703922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}