{"id":"W3163464093","doi":"10.1038/s41525-021-00199-4","title":"Transcriptome-wide association study uncovers the role of essential genes in anthracycline-induced cardiotoxicity","year":2021,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; University of British Columbia; Government of Canada","keywords":"Cardiotoxicity; Genome-wide association study; Transcriptome; Anthracycline; Biology; Gene; Cardiomyopathy; Genetics; Genetic association; Candidate gene; Pharmacogenetics; Computational biology; Single-nucleotide polymorphism; Gene expression; Cancer research; Bioinformatics; Internal medicine; Medicine; Genotype; Heart failure; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080651,0.0001757204,0.0002474317,0.0004127564,0.0001707121,0.0003146335,0.0001252446,0.0001960173,0.001596723],"category_scores_gemma":[0.0005955413,0.0000993189,0.0003588707,0.0006045028,0.0001548493,0.00008403001,0.0002543314,0.0003247057,0.0001303352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001140311,"about_ca_system_score_gemma":0.0001430531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006424387,"about_ca_topic_score_gemma":0.001181131,"domain_scores_codex":[0.9998164,0.00004427384,0.00001602304,0.00006724942,0.00003100933,0.00002517915],"domain_scores_gemma":[0.9996419,0.0001200955,0.0001307731,0.00003726145,0.00002532277,0.00004472132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001727707,0.0001185696,0.6976826,0.0001545526,0.0009130297,0.0007619698,0.00009925301,0.001054796,0.2817788,0.0003878765,0.0008837526,0.01443706],"study_design_scores_gemma":[0.00001989538,0.00008795883,0.9916263,0.000006801428,0.0002256445,0.0004631687,0.00005067122,0.001201714,0.005422993,0.0001943188,0.0006951587,0.000005299413],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996527,0.0006270548,0.001366419,0.0001045194,0.00001075172,0.000005250363,0.0009357081,0.00002890328,0.0003942449],"genre_scores_gemma":[0.9984097,0.0001569638,0.0005224063,0.00004461792,0.000006273391,0.000005273191,0.0006562787,0.000005456438,0.0001929678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596723,"threshold_uncertainty_score":0.00534153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357389050185894,"score_gpt":0.2763712899626303,"score_spread":0.2627973994607714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}