{"id":"W3163517945","doi":"10.2217/nmt-2021-0005","title":"Ozanimod for the Treatment of Relapsing Forms of Multiple Sclerosis","year":2021,"lang":"en","type":"article","venue":"Neurodegenerative Disease Management","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Multiple Sclerosis Society of Canada; National Multiple Sclerosis Society","keywords":"Fingolimod; Medicine; Multiple sclerosis; Sphingosine-1-phosphate receptor; Tolerability; Receptor; Clinical trial; Bioinformatics; Internal medicine; Adverse effect; Sphingosine-1-phosphate; Immunology; Sphingosine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006150235,0.0001238996,0.0001458359,0.00002401066,0.00009628764,0.00001268438,0.0001003392,0.00002146617,0.000008496998],"category_scores_gemma":[0.00004211767,0.00008748215,0.0002074281,0.0000820962,0.0000462937,0.00000332799,0.00005699213,0.00001353166,3.758936e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007606601,"about_ca_system_score_gemma":0.0000305503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003109934,"about_ca_topic_score_gemma":0.000008638151,"domain_scores_codex":[0.9992245,0.0000421746,0.0002006059,0.0002791923,0.0001152219,0.0001383314],"domain_scores_gemma":[0.9993271,0.00003103713,0.00009029077,0.0003800782,0.0001193928,0.00005209388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004970518,0.0006664064,0.00180568,0.0001197996,0.0003958909,0.000004272022,0.0001762005,0.005511201,0.9701377,0.00475864,0.00043333,0.0154938],"study_design_scores_gemma":[0.001691561,0.0002131117,0.009906327,0.00002243912,0.0002824339,2.386533e-7,0.000226814,0.00161341,0.9683465,0.00008712464,0.01749714,0.0001128637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748436,0.006055352,0.0178527,0.0001217936,0.0002292841,0.0005267423,0.0001411644,0.000004805655,0.0002245291],"genre_scores_gemma":[0.9950864,0.002912548,0.001058543,0.0001366196,0.0001229393,0.0001444477,0.00012641,0.0000177466,0.0003942868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02024283,"threshold_uncertainty_score":0.3567418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393061890345375,"score_gpt":0.2532120185054075,"score_spread":0.2192813996019537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}