{"id":"W3163542892","doi":"10.3390/cancers13102370","title":"Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; Institute of Biomedical Sciences, Academia Sinica; Universitätsklinikum Hamburg-Eppendorf; Biomedical Research Council; Cancer Council Tasmania; Medical Research Council; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; U.S. Army; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Norges Forskningsråd; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Stockholms Läns Landsting; Seoul National University Hospital; Karolinska Institutet; Instituto de Salud Carlos III; National Research Foundation of Korea; Ministry of Education, Science and Technology; Ovarian Cancer Research Fund; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; National Breast Cancer Foundation; Seoul National University; King's College London; Academy of Finland; Cancer Australia; Agence Nationale de la Recherche; Robert Bosch Stiftung; Agency for Science, Technology and Research; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Engineering and Physical Sciences Research Council; European Commission; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Gentofte Hospital; Kuopion Yliopistollinen Sairaala; Academia Sinica; National Research Foundation Singapore; National Research Foundation; National Institute for Health and Care Research; Fondation de France; California Breast Cancer Research Program; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Cambridge; Government of Canada; National Medical Research Council; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Wellcome Trust; Fondation du cancer du sein du Québec; Japan Agency for Medical Research and Development; Itä-Suomen Yliopisto; Center for Agroforestry, University of Missouri; Genome Canada; Deutsches Krebsforschungszentrum; University of Southern California; Cancer Research UK; Kreftforeningen; Cancer Council NSW; Susan G. Komen for the Cure; Taiwan Biobank; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; University of California; University of California, San Francisco; U.S. Department of Health and Human Services; Breast Cancer Research Foundation; Yayasan Sime Darby","keywords":"Breast cancer; Single-nucleotide polymorphism; Candidate gene; Genome-wide association study; Biology; Gene; Estrogen; Bioinformatics; Computational biology; Genetics; Medicine; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01269716,0.00143555,0.001912709,0.00200329,0.0007411001,0.001735218,0.001114665,0.001485955,0.001861414],"category_scores_gemma":[0.0225537,0.0006317264,0.00307958,0.003474975,0.001538242,0.00155785,0.001656394,0.001449512,0.0003030026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111996,"about_ca_system_score_gemma":0.0005455761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001565907,"about_ca_topic_score_gemma":0.00233509,"domain_scores_codex":[0.9863364,0.00752168,0.0009415335,0.003460821,0.001044145,0.0006954526],"domain_scores_gemma":[0.9617129,0.03006615,0.004345855,0.002582652,0.0006518756,0.0006406367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008417382,0.00008783188,0.9717674,0.0002218006,0.009380007,0.001364278,0.0003686961,0.0004902827,0.004004965,0.0003881416,0.0001811989,0.0109036],"study_design_scores_gemma":[0.00006247454,0.0003866769,0.9911678,0.00003290869,0.003329232,0.0006574927,0.0002146035,0.001223416,0.0004920445,0.001650948,0.0007542711,0.000028063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983876,0.008194029,0.005816491,0.0007358275,0.0001224066,0.00002413815,0.0003562151,0.00004918471,0.0008256288],"genre_scores_gemma":[0.9958127,0.001056541,0.001941663,0.0004570174,0.0001447569,0.00003753968,0.0003227131,0.00003206279,0.0001949892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269716,"threshold_uncertainty_score":0.06714982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009411385777699535,"score_gpt":0.2515333431666947,"score_spread":0.2421219573889951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}