{"id":"W3163554303","doi":"10.1158/1055-9965.epi-20-1848","title":"Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study","year":2021,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory Biomarkers in Disease Prognosis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Instituto de Salud Carlos III; Centers for Disease Control and Prevention; Institut Gustave-Roussy; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Deutsche Krebshilfe; University of Pittsburgh; World Cancer Research Fund; Danish Cancer Society Research Center; Health and Medical Research Fund; Fred Hutchinson Cancer Research Center; Hellenic Health Foundation; Kræftens Bekæmpelse; American Cancer Society; Johns Hopkins University; Canadian Cancer Society; Centre International de Recherche sur le Cancer; European Commission; World Health Organization; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Hazard ratio; Oncology; Medicine; Proportional hazards model; Internal medicine; Confounding; Cancer; Confidence interval; Genotype; Biology; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02095438,0.001136126,0.0009468772,0.0009995317,0.0009172946,0.0009524543,0.001260893,0.001220066,0.002109401],"category_scores_gemma":[0.03551792,0.0005768693,0.001415931,0.001588618,0.001035415,0.0004636797,0.0006844485,0.0007904536,0.0002282458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00073382,"about_ca_system_score_gemma":0.001227264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006192144,"about_ca_topic_score_gemma":0.002936646,"domain_scores_codex":[0.9783806,0.01644529,0.0008510801,0.002487801,0.001351797,0.0004834663],"domain_scores_gemma":[0.9803752,0.008814676,0.003549534,0.005766893,0.0007978283,0.0006958225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02167307,0.001013139,0.9298356,0.0002347725,0.01004203,0.002407613,0.000697205,0.004156998,0.003991208,0.005104448,0.002450235,0.0183937],"study_design_scores_gemma":[0.01622236,0.007561369,0.8408035,0.000278359,0.01398976,0.009768155,0.0005224709,0.08856598,0.003919485,0.01193487,0.006026064,0.0004076795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829609,0.0005460099,0.01432919,0.0003660361,0.00005862444,0.000368758,0.0007090497,0.00007986963,0.0005815011],"genre_scores_gemma":[0.9945921,0.00008950367,0.00448823,0.0001095044,0.00002321798,0.0001964455,0.0003045303,0.00002328143,0.0001731104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02095438,"threshold_uncertainty_score":0.1108187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05455309707416246,"score_gpt":0.3696520508590649,"score_spread":0.3150989537849025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}