{"id":"W3163611512","doi":"10.1101/2021.05.19.444814","title":"Genetic analysis of <i>Caenorhabditis elegans pry-1/Axin</i> suppressors identifies genes involved in reproductive structure development, stress response, and aging","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Caenorhabditis elegans; Biology; Gene; Genetics; Mutant; RNA interference; Phenotype; Gene family; Transcriptome; Cell biology; Gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008791894,0.0006219189,0.0001935343,0.0005568468,0.0002352782,0.000194414,0.0002512172,0.0002272316,0.001441499],"category_scores_gemma":[0.00007088523,0.0001683942,0.0003629402,0.0001482092,0.0002565017,0.00008998147,0.0002231501,0.0005375986,0.0004026583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004559954,"about_ca_system_score_gemma":0.000226375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001914177,"about_ca_topic_score_gemma":0.002734883,"domain_scores_codex":[0.9998952,0.000006712404,0.00001008764,0.00003400791,0.00003270502,0.00002127641],"domain_scores_gemma":[0.9998468,0.00002174326,0.00005732412,0.00001049139,0.00001431342,0.00004934433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002598122,0.000009139256,0.0001115272,0.000009550577,0.000002560352,0.00004386077,0.000002734752,0.00003644445,0.999519,0.00002886303,0.00002280096,0.0001876596],"study_design_scores_gemma":[0.00001810076,0.0001159627,0.01546422,0.000008397086,0.00002230425,0.0003847687,0.00002576873,0.001755539,0.9809728,0.00003887947,0.001185175,0.000008082495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940084,0.0003652416,0.002578218,0.00007330671,0.0000292059,0.00003874722,0.00171783,0.000186514,0.001002548],"genre_scores_gemma":[0.991048,0.00020729,0.003011113,0.00006790597,0.00000784532,0.00004513482,0.002320051,0.00009573493,0.003196971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001914177,"threshold_uncertainty_score":0.004822314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007777655423017265,"score_gpt":0.2100006147443068,"score_spread":0.2022229593212896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}