{"id":"W3163623036","doi":"10.1126/sciadv.abf4155","title":"Structure of the murine lysosomal multienzyme complex core","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; McGill University; University Health Network","funders":"Fonds de Recherche du Québec - Santé; Princess Margaret Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Cathepsin A; Gangliosidosis; Lysosome; Neuraminidase; Glycoprotein; Sialidase; Cathepsin; Cell biology; Enzyme; Biochemistry; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026733,0.00008834772,0.0001776568,0.00006341137,0.0002282797,0.00001791437,0.0004141828,0.00002581295,0.0004813279],"category_scores_gemma":[0.0006707081,0.00005347007,0.00006301337,0.001499711,0.001502582,0.0002423177,0.0002488838,0.0001539902,0.00000657596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005278692,"about_ca_system_score_gemma":0.0004917516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002075903,"about_ca_topic_score_gemma":0.00009443514,"domain_scores_codex":[0.9982365,0.00002024509,0.0001612865,0.0003079812,0.0009603192,0.0003137156],"domain_scores_gemma":[0.9988883,0.00004154135,0.00006831557,0.0004527231,0.0004458839,0.0001032597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002602024,0.00005906563,0.06718938,0.00005814547,0.000005107,0.00001996082,0.0002003306,0.00006731496,0.9240674,0.0003391402,0.00007440613,0.00789369],"study_design_scores_gemma":[0.0006603678,0.00008706732,0.2951104,0.00005585824,0.00001018052,0.0001023328,0.0007978361,0.0002476279,0.6975839,0.0007184817,0.004542282,0.00008364907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954624,0.001199447,0.00001973508,0.000875554,0.0002146574,0.0001809571,0.00001875133,0.00001641142,0.002012122],"genre_scores_gemma":[0.9968074,0.00002049528,0.002142159,0.0002542491,0.00004613454,0.000001852204,0.000004350968,0.000006217879,0.0007171462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.227921,"threshold_uncertainty_score":0.5536325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03815710867890843,"score_gpt":0.3494197208424807,"score_spread":0.3112626121635723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}