{"id":"W3163632791","doi":"10.1038/s41380-021-01146-6","title":"Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; Health Sciences Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Research Manitoba","keywords":"Neuroscience; Excitatory postsynaptic potential; Prefrontal cortex; Thalamus; Postsynaptic potential; Schizophrenia (object-oriented programming); Psychology; Inhibitory postsynaptic potential; Cognition; Medicine; Internal medicine; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130904,0.0003985082,0.0003141137,0.0002020042,0.0002527784,0.0005250936,0.0003482312,0.0003195559,0.001830663],"category_scores_gemma":[0.0002131321,0.0001884577,0.0003054479,0.00008419796,0.0004574799,0.0003476481,0.0004017864,0.0007044315,0.0002988435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007307571,"about_ca_system_score_gemma":0.0003328133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00337871,"about_ca_topic_score_gemma":0.007916084,"domain_scores_codex":[0.9998795,0.00001823066,0.000006325864,0.00002747757,0.00002709815,0.00004148044],"domain_scores_gemma":[0.9998983,0.000006575236,0.00004663961,0.000007883604,0.0000112826,0.00002925571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000651033,0.00002766894,0.003837754,0.00005929111,0.0000496139,0.000305685,0.00008101113,0.0002780794,0.9896713,0.00113454,0.0002338454,0.003670255],"study_design_scores_gemma":[0.0003339962,0.001086103,0.3221714,0.0001335029,0.0003266565,0.003185059,0.001188154,0.01379217,0.6471487,0.004378459,0.006159924,0.00009594565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912379,0.0009330316,0.004651251,0.0003938934,0.00002947059,0.000009987963,0.000500194,0.00009152931,0.002152712],"genre_scores_gemma":[0.9969612,0.0002541894,0.001093301,0.00007798104,0.000004701231,0.000007443433,0.0002461703,0.00002984913,0.001324968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00337871,"threshold_uncertainty_score":0.006718099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03165821035280258,"score_gpt":0.3196713589220029,"score_spread":0.2880131485692003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}