{"id":"W3163673795","doi":"10.1080/23723556.2021.1915075","title":"Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A","year":2021,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Tel Aviv University; Israel Cancer Association; Israel Cancer Research Fund; U.S. Department of Defense","keywords":"Aneuploidy; Biomarker; Spindle checkpoint; Mitosis; Medicine; Spindle apparatus; Biology; Genetics; Gene; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010675,0.0003450694,0.0005742214,0.0004314612,0.0004012895,0.001002888,0.0002320912,0.0006552893,0.002509488],"category_scores_gemma":[0.001133446,0.0001123843,0.0002716253,0.0002017886,0.0004300396,0.0006783576,0.0003465007,0.001145682,0.0003756745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007986146,"about_ca_system_score_gemma":0.0006854943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004330755,"about_ca_topic_score_gemma":0.000863693,"domain_scores_codex":[0.9997266,0.0001160647,0.00002344451,0.00004379193,0.00006812523,0.00002184914],"domain_scores_gemma":[0.9993487,0.0003329653,0.0001049363,0.00003924759,0.0001129577,0.00006122519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00236827,0.000416651,0.02006796,0.001497291,0.0001404482,0.002696601,0.0002807932,0.005437371,0.5363728,0.02238719,0.008198589,0.4001361],"study_design_scores_gemma":[0.0003791311,0.00706799,0.09505071,0.0008993974,0.0006232969,0.02454427,0.0008224178,0.01216432,0.3902903,0.04569917,0.4223003,0.0001587092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3909022,0.4632793,0.02836367,0.06128687,0.002789098,0.00039076,0.0006086656,0.0003484755,0.05203104],"genre_scores_gemma":[0.9052035,0.07548967,0.005870038,0.00429096,0.001073827,0.0001453066,0.0002100408,0.00005790666,0.00765869],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002509488,"threshold_uncertainty_score":0.008395016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009684732904250872,"score_gpt":0.2680316825785255,"score_spread":0.2583469496742746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}