{"id":"W3163682672","doi":"10.1084/jem.20201908","title":"A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; Fogarty International Center; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Office of AIDS Research; District of Columbia Developmental Center for AIDS Research; National Institute on Aging; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; NIH Office of the Director; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Viremia; Immunology; CD8; Humanized mouse; Immune system; In vivo; Biology; T cell; Cell; Disease; Cancer research; Virology; Virus; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002393147,0.000499715,0.0003273739,0.0001684594,0.0001567979,0.0004393659,0.0004753454,0.0005509607,0.001768124],"category_scores_gemma":[0.0001580188,0.0001398201,0.0002950291,0.0001142493,0.0002116913,0.0003817513,0.0002848961,0.001117614,0.0002594623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071741,"about_ca_system_score_gemma":0.0002716729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958284,"about_ca_topic_score_gemma":0.0004889044,"domain_scores_codex":[0.9998943,0.00002599926,0.00000566999,0.0000260436,0.00002980602,0.00001817019],"domain_scores_gemma":[0.9998527,0.00004503191,0.00002643702,0.0000304802,0.00001295364,0.00003232108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004592409,0.00044227,0.0007602089,0.0000963747,0.00001627733,0.0002645974,0.00004990569,0.005253381,0.9854715,0.002585121,0.0002577348,0.004343385],"study_design_scores_gemma":[0.0001724433,0.006605409,0.001935964,0.00004342489,0.00007422497,0.001418598,0.0001298472,0.04480805,0.9345339,0.001591942,0.008652442,0.00003378372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568182,0.0008067226,0.03813933,0.0001362014,0.0001312887,0.0001633219,0.0008984047,0.0001816508,0.002724981],"genre_scores_gemma":[0.98443,0.0007020132,0.01170504,0.00003027722,0.00001728531,0.0001822855,0.0004317037,0.00002478492,0.002476569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768124,"threshold_uncertainty_score":0.005914927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006259802925807,"score_gpt":0.3676526681099289,"score_spread":0.2670266878173482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}