{"id":"W3163737568","doi":"10.21203/rs.3.rs-457070/v1","title":"Genomic Signatures Define Three Subtypes of EGFR-Mutant Stage II-III NSCLC With Distinct Adjuvant Therapy Outcomes","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Guangdong Provincial People's Hospital; National Natural Science Foundation of China","keywords":"Mutant; Stage (stratigraphy); Adjuvant therapy; Adjuvant; Oncology; Computational biology; Internal medicine; Biology; Medicine; Cancer research; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200333,0.0001745701,0.0002493949,0.0005349533,0.0001261393,0.0003571512,0.00009868957,0.0002015432,0.00179022],"category_scores_gemma":[0.000738488,0.00005643768,0.0002090359,0.000346315,0.0001651328,0.0001244506,0.0002591338,0.0001869871,0.0002490781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631492,"about_ca_system_score_gemma":0.0001548354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006022804,"about_ca_topic_score_gemma":0.0009052158,"domain_scores_codex":[0.9999014,0.00002494944,0.00001020879,0.00002122296,0.00001965643,0.00002244999],"domain_scores_gemma":[0.9997879,0.000058665,0.00007853023,0.00001734503,0.00002019972,0.00003744237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00213369,0.00008125224,0.9333705,0.0000326509,0.0001474267,0.0003317063,0.00009245113,0.0005636883,0.04101014,0.0003769509,0.0004284525,0.02143106],"study_design_scores_gemma":[0.0000266378,0.0002201107,0.9941843,0.000004754009,0.00005239107,0.0007339282,0.0000989266,0.0009131206,0.002756874,0.0005321431,0.0004720402,0.000004740097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984439,0.0001414823,0.0003101783,0.00004503107,0.00000313524,0.000007337638,0.0004768826,0.000006251018,0.0005658398],"genre_scores_gemma":[0.9987534,0.00003878831,0.0002375325,0.00002173138,0.000003639624,0.000005787502,0.0007008791,0.000003052995,0.0002349837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179022,"threshold_uncertainty_score":0.005988896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05021941120429346,"score_gpt":0.4023070969264186,"score_spread":0.3520876857221252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}