{"id":"W3163801212","doi":"10.1158/2159-8290.cd-20-1690","title":"Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Children's Hospital; BC Cancer Agency","funders":"Canadian Institutes of Health Research; National Institutes of Health; Lotte and John Hecht Memorial Foundation; National Cancer Institute; St. Baldrick's Foundation","keywords":"Anoikis; Ewing's sarcoma; Suppressor; Cancer research; Sarcoma; Biology; Computational biology; Bioinformatics; Medicine; Cancer; Genetics; Pathology; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306616,0.0003106046,0.0001864772,0.0002519567,0.0001242782,0.0002138272,0.0001528695,0.000205268,0.0007716347],"category_scores_gemma":[0.0001131655,0.0001066661,0.0001873037,0.0001781143,0.0001291404,0.0001003212,0.0002111034,0.0002712379,0.0003143217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297523,"about_ca_system_score_gemma":0.0001468625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003002743,"about_ca_topic_score_gemma":0.000478957,"domain_scores_codex":[0.9998969,0.00001204642,0.0000126493,0.00001753253,0.00003777857,0.00002310594],"domain_scores_gemma":[0.9998615,0.00002929604,0.0000467849,0.00001345252,0.00002153096,0.00002737079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001632867,0.000007426485,0.0001869392,0.000006357743,0.000001593698,0.00002298345,0.000002391384,0.00002201514,0.9994103,0.00001563059,0.000009475313,0.0002985916],"study_design_scores_gemma":[0.000007292822,0.0001648422,0.004924558,0.000002540472,0.00001470874,0.0003485583,0.0000163095,0.0006292916,0.9924632,0.0000278166,0.001398737,0.000002144972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942371,0.0004982324,0.003725781,0.00006633804,0.000008830937,0.00004991752,0.0005800259,0.00008024171,0.00075343],"genre_scores_gemma":[0.9917099,0.0004053121,0.004764697,0.00006111052,0.000004858622,0.00002997574,0.001324488,0.0000257848,0.001673932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007716347,"threshold_uncertainty_score":0.002581418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907727552156805,"score_gpt":0.3272335178842291,"score_spread":0.308156242362661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}