{"id":"W3163801212","doi":"10.1158/2159-8290.cd-20-1690","title":"Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Children's Hospital; BC Cancer Agency","funders":"Canadian Institutes of Health Research; National Institutes of Health; Lotte and John Hecht Memorial Foundation; National Cancer Institute; St. Baldrick's Foundation","keywords":"Anoikis; Ewing's sarcoma; Suppressor; Cancer research; Sarcoma; Biology; Computational biology; Bioinformatics; Medicine; Cancer; Genetics; Pathology; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195786,0.0001158201,0.0001946741,0.00003536328,0.00005012365,0.00005385788,0.0001528895,0.00008754884,0.00001663037],"category_scores_gemma":[0.0001579988,0.0001166369,0.0001140399,0.0001288797,0.00005715462,0.00002252967,0.0001249566,0.00008833729,8.102368e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004166509,"about_ca_system_score_gemma":0.0004606457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648023,"about_ca_topic_score_gemma":0.0001715371,"domain_scores_codex":[0.9988973,0.00005815873,0.000216044,0.0003497816,0.0001431239,0.0003356001],"domain_scores_gemma":[0.9994925,0.00001702728,0.00006923471,0.0002631066,0.0000999837,0.00005820877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002365648,0.00004418209,0.02752683,0.0001541877,0.00004990066,0.000009868852,0.00005175563,0.0007097098,0.970425,0.00003023449,0.0003917962,0.0003699899],"study_design_scores_gemma":[0.0008725253,0.00009403405,0.008640594,0.0001518076,0.000008510968,0.000004220079,0.0001470487,0.0003471547,0.9886048,0.0001409331,0.0008484252,0.0001399047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955442,0.002142893,0.00126113,0.0002047004,0.00008792113,0.0004393946,0.0001218441,0.000003869191,0.0001940734],"genre_scores_gemma":[0.9954582,0.0002578253,0.001131943,0.00007632588,0.00009729411,0.00007686394,0.0001021836,0.00002488341,0.002774482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01888623,"threshold_uncertainty_score":0.4756316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907727552156805,"score_gpt":0.3272335178842291,"score_spread":0.308156242362661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}