{"id":"W3163966296","doi":"10.2196/22533","title":"Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service","year":2021,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cardiolipin; Internal medicine; Population; Phosphocreatine; Placebo; Bezafibrate; Crossover study; Physical therapy; Cardiology; Endocrinology; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01280221,0.005182455,0.008350585,0.001655861,0.003000459,0.00278996,0.003522048,0.006106848,0.04072509],"category_scores_gemma":[0.01070438,0.002379337,0.003556436,0.001818903,0.003264571,0.002564598,0.001861453,0.007806702,0.007370056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002933592,"about_ca_system_score_gemma":0.009532196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097919,"about_ca_topic_score_gemma":0.004310403,"domain_scores_codex":[0.9937863,0.003167622,0.0005606093,0.0008553409,0.000608686,0.001021411],"domain_scores_gemma":[0.993912,0.0009549436,0.001213856,0.0008699443,0.001293688,0.001755507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9589133,0.02384023,0.0002625262,0.001875854,0.0005924533,0.00009315286,0.00009781635,0.0005915156,0.002418903,0.0005822132,0.00333781,0.007394069],"study_design_scores_gemma":[0.9473636,0.04409251,0.0007798988,0.0002277336,0.0003226449,0.00002372471,0.00003678966,0.0003853777,0.0004056791,0.0004647902,0.005859727,0.00003752332],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01885451,0.0004804402,0.001885411,0.0004276115,0.0006616115,0.9742313,0.001931871,0.0001813386,0.001345958],"genre_scores_gemma":[0.01329487,0.0003144529,0.002657545,0.0003523476,0.0001734955,0.9817578,0.0003623838,0.00001317352,0.001073943],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04072509,"threshold_uncertainty_score":0.136239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1329705243733244,"score_gpt":0.4461915745825371,"score_spread":0.3132210502092128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}