{"id":"W3163972164","doi":"10.1136/annrheumdis-2021-eular.544","title":"POS0594 MEANINGFUL IMPROVEMENT AND WORSENING IN PATIENTS WHO DO NOT ACHIEVE LDA AND SWITCH THERAPY TO A NEW BIOLOGIC OR TARGETED THERAPY: RESULTS FROM THE CORRONA REGISTRY","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Instituto de Investigación Marqués de Valdecilla; Canadian Institutes of Health Research; Regeneron Pharmaceuticals; Patient-Centered Outcomes Research Institute; Gilead Sciences; Sanofi; Pfizer; Amgen","keywords":"Medicine; Rheumatoid arthritis; Internal medicine; Combination therapy; Physical therapy; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002095649,0.0003149228,0.0008661778,0.0012157,0.0004705227,0.001559174,0.0005605221,0.0004890677,0.00161675],"category_scores_gemma":[0.00581335,0.000249888,0.00120923,0.001898501,0.000423025,0.001262159,0.001095152,0.0009617332,0.0005093626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00053715,"about_ca_system_score_gemma":0.0007869457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004326705,"about_ca_topic_score_gemma":0.006651265,"domain_scores_codex":[0.9979291,0.000687929,0.0002892429,0.0004099298,0.0004122145,0.0002716898],"domain_scores_gemma":[0.9951059,0.001001407,0.002651985,0.0005183638,0.0003932127,0.0003291724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001702627,0.00007493842,0.9931149,0.00005677592,0.0003297347,0.00005223325,0.00006513004,0.0001001032,0.00006649429,0.00009985564,0.0007482817,0.003588869],"study_design_scores_gemma":[0.0001310923,0.0002513087,0.9972511,0.00004472129,0.0002894985,0.0001877282,0.0002494824,0.000175772,0.00008625674,0.000112389,0.001204082,0.00001666176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870183,0.001333029,0.000182412,0.0001389234,0.00004510068,0.00005595036,0.007073935,0.00002099666,0.004131399],"genre_scores_gemma":[0.9904099,0.0005411505,0.0001964971,0.0001461032,0.00006510627,0.00006909902,0.00786362,0.00001563577,0.0006929442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004326705,"threshold_uncertainty_score":0.01108301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05825499397429516,"score_gpt":0.3206503309199542,"score_spread":0.262395336945659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}