{"id":"W3164018990","doi":"10.1016/j.jaip.2021.05.004","title":"A Toolkit and Framework for Optimal Laboratory Evaluation of Individuals with Suspected Primary Immunodeficiency","year":2021,"lang":"en","type":"review","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Janssen Pharmaceuticals; Takeda Pharmaceutical Company; Jeffrey Modell Foundation; Canadian Institutes of Health Research; Horizon Therapeutics; Novartis; Fonds de Recherche du Québec - Santé; CSL Behring; Merck; UCB; Cidara Therapeutics; American Association for Clinical Chemistry","keywords":"Medicine; Disease; Intensive care medicine; Immunity; Primary immunodeficiency; Test (biology); Identification (biology); Diagnostic test; Immunodeficiency; Primary care; Human immunodeficiency virus (HIV); Immunology; Pediatrics; Immune system; Pathology; Biology; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008293947,0.002264691,0.003760923,0.005531218,0.0007043734,0.00343655,0.003451814,0.004691896,0.003894401],"category_scores_gemma":[0.01370676,0.0008631237,0.001787204,0.002404379,0.001849706,0.004113473,0.003845461,0.009503098,0.003559729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003804612,"about_ca_system_score_gemma":0.009537932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005757773,"about_ca_topic_score_gemma":0.007314693,"domain_scores_codex":[0.9953297,0.001423985,0.001090427,0.0004432295,0.001427003,0.0002856769],"domain_scores_gemma":[0.9904134,0.003985749,0.00124677,0.000288803,0.003246652,0.0008185838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005168382,0.00009699981,0.000823131,0.008051221,0.0001211388,0.000490376,0.0001441785,0.0006075604,0.0003818742,0.008162656,0.1632586,0.8178104],"study_design_scores_gemma":[0.00008188947,0.0001318788,0.002866425,0.03783405,0.0003133542,0.003762758,0.0002871414,0.0006827374,0.0002785616,0.01031841,0.9433615,0.00008129343],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001573829,0.9692329,0.008209761,0.01565112,0.00253488,0.0001153347,0.0001682157,0.0003973975,0.003533054],"genre_scores_gemma":[0.003394171,0.9388235,0.03736294,0.01253742,0.004502106,0.0002923864,0.0007201596,0.00005756408,0.002309828],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008293947,"threshold_uncertainty_score":0.04386306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04601270829216463,"score_gpt":0.38940370913124,"score_spread":0.3433910008390753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}