{"id":"W3164038497","doi":"10.21203/rs.3.rs-460311/v1","title":"Glycine transporter-1 antagonist provides 1 neuroprotection in vivo","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Glycine; Neuroprotection; In vivo; NMDA receptor; Pharmacology; Glycine receptor; Antagonist; Neurotransmission; Glutamate receptor; Receptor; Transporter; Biology; Chemistry; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002111019,0.0009121699,0.0009795411,0.0004885559,0.0002761745,0.0003050824,0.000427034,0.0006352048,0.003278586],"category_scores_gemma":[0.0001668996,0.0002452161,0.0003669502,0.0002339408,0.0003847664,0.0004113127,0.0001583905,0.001262156,0.000966624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002652242,"about_ca_system_score_gemma":0.0004666467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006496818,"about_ca_topic_score_gemma":0.001107174,"domain_scores_codex":[0.9998347,0.00002880017,0.00001576044,0.00003475701,0.00002753652,0.00005848324],"domain_scores_gemma":[0.9998214,0.00002522371,0.00003840131,0.00002659991,0.00002005708,0.00006845533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003863642,0.0006928807,0.00007546244,0.0001104078,0.00003609416,0.0001378794,0.00003705785,0.00009320216,0.9917414,0.0001432079,0.000483922,0.002584964],"study_design_scores_gemma":[0.0004646882,0.009163409,0.002212327,0.00001679262,0.0000664752,0.0003800748,0.00005469932,0.0008535358,0.9841214,0.0001478305,0.002504843,0.00001380196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918354,0.002040272,0.001698528,0.0004230293,0.0002313262,0.00009981472,0.001025373,0.0003317114,0.00231475],"genre_scores_gemma":[0.9863394,0.002191215,0.002024779,0.0002317943,0.0001014885,0.0001765914,0.002052878,0.00006312811,0.006818663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003278586,"threshold_uncertainty_score":0.01096797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129593717719613,"score_gpt":0.430917158085415,"score_spread":0.3013234403658021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}