{"id":"W3164040616","doi":"10.1101/2021.05.27.21257096","title":"Early Covid-19 Treatment With SARS-CoV-2 Neutralizing Antibody Sotrovimab","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"Vir Biotechnology","keywords":"Placebo; Medicine; Clinical endpoint; Interim analysis; Internal medicine; Adverse effect; Confidence interval; Population; Coronavirus disease 2019 (COVID-19); Randomized controlled trial; Disease; Pathology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005315274,0.0009147737,0.001512396,0.0005753767,0.0002375281,0.0003481239,0.0005780465,0.0006056768,0.00003987169],"category_scores_gemma":[0.0002622655,0.0007069609,0.0005995249,0.000618396,0.0003305885,0.0001319246,0.0005994208,0.001335176,0.0001677593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001241289,"about_ca_system_score_gemma":0.004612426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006312764,"about_ca_topic_score_gemma":0.0004846983,"domain_scores_codex":[0.9948826,0.0003050515,0.0006765601,0.001758108,0.001249911,0.001127749],"domain_scores_gemma":[0.9968215,0.0002315428,0.0002732122,0.0020688,0.0003502947,0.0002547092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001269873,0.001111121,0.4891534,0.001658431,0.001310217,0.01028599,0.002659358,0.000009285243,0.4902368,0.00009718684,0.0002750815,0.001933285],"study_design_scores_gemma":[0.01066508,0.003376729,0.04120712,0.001246143,0.001245792,0.0007544136,0.0005525589,0.0004777374,0.6766093,0.0001900753,0.2621035,0.001571554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887138,0.001793294,0.001308238,0.002233333,0.0004509481,0.001641863,0.00004856136,0.0004072554,0.003402697],"genre_scores_gemma":[0.9604791,0.0001550009,0.0009377018,0.03696001,0.0005747551,0.0003678611,0.0001465521,0.0001965639,0.0001825003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4479463,"threshold_uncertainty_score":0.9995381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0862114640864935,"score_gpt":0.3971114174822251,"score_spread":0.3108999533957316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}