{"id":"W3164056201","doi":"10.1128/mmbr.00064-21","title":"Large Clostridial Toxins: Mechanisms and Roles in Disease","year":2021,"lang":"en","type":"article","venue":"Microbiology and Molecular Biology Reviews","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Clostridium difficile toxin B; Internalization; Clostridium perfringens; Virulence; Toxin; Secretion; Clostridium; Cytolysin; Clostridia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005014801,0.0007610443,0.001020261,0.0009320714,0.0003242284,0.001264879,0.0005877894,0.001382991,0.002066175],"category_scores_gemma":[0.0003592985,0.0002019497,0.0003334428,0.001217497,0.0006977195,0.001090449,0.000766203,0.001104675,0.001120394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009293929,"about_ca_system_score_gemma":0.001043524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009118915,"about_ca_topic_score_gemma":0.0007442744,"domain_scores_codex":[0.9996842,0.00005511441,0.00003283073,0.00005443031,0.00009313096,0.00008036947],"domain_scores_gemma":[0.9998449,0.00004248452,0.00003178353,0.00000458895,0.00003573273,0.00004040817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003937421,0.0001200843,0.001190551,0.01377773,0.00008923125,0.001377612,0.0004382447,0.0008033958,0.0433014,0.0147956,0.0379957,0.8857166],"study_design_scores_gemma":[0.00003298598,0.0003948167,0.005271892,0.002442466,0.0001006736,0.00337492,0.0003159202,0.0002225411,0.005104528,0.008345809,0.974345,0.00004848695],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000864439,0.9973441,0.0001999662,0.0005485789,0.0002426498,0.000003989885,0.00001478855,0.00001397709,0.0007674696],"genre_scores_gemma":[0.004472157,0.9935712,0.0002632481,0.0002857725,0.0003696168,0.000009663198,0.00004361661,0.000003505815,0.0009813135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002066175,"threshold_uncertainty_score":0.006911993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724904404042995,"score_gpt":0.3104441138385123,"score_spread":0.2931950697980824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}