{"id":"W3164102337","doi":"10.1002/alz.12378","title":"Effect of periodontal treatment on preclinical Alzheimer's disease—Results of a trial emulation approach","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Bundesministerium für Bildung und Forschung; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; European Commission; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"Medicine; Percentile; Atrophy; Confidence interval; Magnetic resonance imaging; Internal medicine; Cohort; Population; Clinical trial; Neuroimaging; Periodontitis; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005694819,0.0002789896,0.0006435852,0.00009101746,0.0001103595,0.00003399385,0.0002276912,0.0002136279,0.0005525913],"category_scores_gemma":[0.0002104271,0.0002306585,0.0004891668,0.0001988049,0.0002163199,0.0001016855,0.0001269276,0.0001844824,0.0001285653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001095436,"about_ca_system_score_gemma":0.0001773925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674826,"about_ca_topic_score_gemma":0.00007165664,"domain_scores_codex":[0.996904,0.001027679,0.0008032614,0.0006002074,0.0003258598,0.0003389951],"domain_scores_gemma":[0.9982657,0.0004613661,0.0003505595,0.0006439043,0.0001270819,0.0001514034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4379915,0.01089424,0.127333,0.0001622041,0.09074233,0.0005127768,0.0008043942,0.0003823015,0.02830664,0.0007679785,0.005660054,0.2964426],"study_design_scores_gemma":[0.1484826,0.01696521,0.1463048,0.0001458063,0.04385299,0.00005213558,0.00007143564,0.0008000193,0.6322011,0.00005358452,0.01017764,0.0008927449],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617894,0.03372523,0.00002468611,0.00005734029,0.0008349004,0.001099442,0.0005300983,0.00003291095,0.001905991],"genre_scores_gemma":[0.9982393,0.00007208186,0.0002943173,0.00001682641,0.0001938397,0.0000897866,0.00100976,0.00002701917,0.00005704352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6038944,"threshold_uncertainty_score":0.9405978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05911451598899627,"score_gpt":0.3643085999912857,"score_spread":0.3051940840022895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}