{"id":"W3164112123","doi":"10.2139/ssrn.3811875","title":"Experimental Evolution Improves Mitochondrial Genome Quality Control in &lt;i&gt;Saccharomyces Cerevisiae&lt;/i&gt; and Extends Its Replicative Lifespan","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Defence Medical Centre","funders":"","keywords":"Saccharomyces cerevisiae; Mitochondrial DNA; Biology; Genetics; Control (management); Genome; Computer science; Yeast; Gene; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003586368,0.0006188528,0.0004573225,0.0003489045,0.0003618166,0.0006474297,0.0008182455,0.0005984494,0.004648438],"category_scores_gemma":[0.0003580511,0.0002395532,0.0003495154,0.000456912,0.0005225816,0.0002969126,0.0008321294,0.001293668,0.0005479721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009076163,"about_ca_system_score_gemma":0.0004707546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002145352,"about_ca_topic_score_gemma":0.002815606,"domain_scores_codex":[0.9997105,0.00006021586,0.00004680599,0.00009148669,0.00004920363,0.00004166649],"domain_scores_gemma":[0.9996219,0.00008396732,0.0001164742,0.00007855958,0.00002489506,0.0000742503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000338634,0.00006600283,0.000233724,0.00006196161,0.00001844972,0.00005843414,0.00002818733,0.0002065054,0.9950264,0.0004211682,0.0001371079,0.003403343],"study_design_scores_gemma":[0.00007850782,0.0003835489,0.00614703,0.0000235248,0.00008634296,0.000272229,0.00007815694,0.002511181,0.9806548,0.0002092907,0.00951414,0.00004120471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864545,0.0009296007,0.005523164,0.0004838192,0.0001464722,0.00005761652,0.001740116,0.0005042755,0.004160385],"genre_scores_gemma":[0.9899551,0.0004381424,0.003771833,0.0002335313,0.00002375615,0.00004458711,0.001187264,0.0004906312,0.003855238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004648438,"threshold_uncertainty_score":0.01555061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0087383708922562,"score_gpt":0.2637521164302736,"score_spread":0.2550137455380174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}