{"id":"W3164128687","doi":"10.3389/fphar.2021.679456","title":"Identification of Docetaxel as a Potential Drug to Promote HDL Biogenesis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Docetaxel; Biogenesis; Chemistry; Taxane; Docking (animal); Virtual screening; Pharmacology; Drug; In silico; Potency; Cytotoxicity; Plasma protein binding; Biochemistry; Cancer research; In vitro; Cell biology; Drug discovery; Biology; Chemotherapy; Medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282275,0.000483327,0.0005388881,0.000508189,0.0001817758,0.0005820043,0.0002917923,0.0002714619,0.001797091],"category_scores_gemma":[0.000159413,0.0001288484,0.0004704229,0.0003367095,0.0001742522,0.000212403,0.0002267463,0.0004441278,0.0003976359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005785624,"about_ca_system_score_gemma":0.0005088698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154127,"about_ca_topic_score_gemma":0.003244691,"domain_scores_codex":[0.9999338,0.00001084567,0.000004695562,0.00001370182,0.00002443232,0.00001247881],"domain_scores_gemma":[0.999944,0.000008869311,0.00001394007,0.000004248948,0.00001404962,0.00001489954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001289549,0.0008080596,0.008833754,0.002285249,0.0002572465,0.001559077,0.00009255434,0.01594615,0.7648368,0.005158494,0.005061683,0.1938713],"study_design_scores_gemma":[0.001537037,0.006145227,0.01317841,0.000424362,0.0010133,0.003422407,0.0001224734,0.03490413,0.7853485,0.001619168,0.1521793,0.0001056671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8706544,0.09069881,0.01908504,0.001677775,0.0003428815,0.0007313825,0.00235588,0.0005333403,0.0139204],"genre_scores_gemma":[0.947021,0.03044454,0.01247795,0.0004720338,0.00005644908,0.0001688677,0.001987683,0.00003102629,0.007340471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797091,"threshold_uncertainty_score":0.006011844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004691811095005334,"score_gpt":0.2665431770564068,"score_spread":0.2618513659614015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}