{"id":"W3164147072","doi":"10.1016/j.scitotenv.2021.147990","title":"Low-dose mono(2-ethylhexyl) phthalate promotes ovarian cancer development through PPARα-dependent PI3K/Akt/NF-κB pathway","year":2021,"lang":"en","type":"article","venue":"The Science of The Total Environment","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Ovarian cancer; Cancer research; Protein kinase B; Phthalate; Peroxisome proliferator-activated receptor; Gene knockdown; Metastasis; Endocrinology; Internal medicine; Chemistry; Biology; Signal transduction; Cancer; Medicine; Cell biology; Receptor; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254336,0.0002682758,0.0002296906,0.0002378846,0.000158086,0.0002604985,0.0001622044,0.0001973997,0.003391457],"category_scores_gemma":[0.0001117091,0.000226029,0.0003469263,0.0001857485,0.0002653173,0.0002439317,0.0002168261,0.0007093543,0.0004469106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466459,"about_ca_system_score_gemma":0.0006087527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654072,"about_ca_topic_score_gemma":0.004779605,"domain_scores_codex":[0.9998546,0.00001868839,0.00001359824,0.00002738026,0.00003345843,0.00005223285],"domain_scores_gemma":[0.9999229,0.000009470215,0.00002040483,0.0000112001,0.000009575645,0.00002654534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001951282,0.0002879528,0.001483891,0.000116478,0.00002353323,0.0001040309,0.00003358705,0.0001248821,0.992428,0.0001494687,0.0002535327,0.0030433],"study_design_scores_gemma":[0.00006563836,0.001029508,0.01680485,0.000009737791,0.00003809435,0.0001827867,0.0001052611,0.0004747595,0.9783876,0.00009240836,0.002802248,0.000007024243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925812,0.002171874,0.00207307,0.0003153069,0.0001391596,0.00003809554,0.0006930191,0.0001440177,0.001844268],"genre_scores_gemma":[0.9896733,0.001350414,0.0007835536,0.0001059664,0.00001764503,0.00005164588,0.0005792523,0.00001684794,0.007421405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003391457,"threshold_uncertainty_score":0.01134551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136731064353794,"score_gpt":0.2270324369115525,"score_spread":0.2156651262680146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}