{"id":"W3164178117","doi":"10.1136/annrheumdis-2021-eular.2513","title":"POS0474 SUBSTANTIAL IMPACT OF AUTOANTIBODY ENRICHMENT ON OUTCOMES IN EARLY RHEUMATOID ARTHRITIS TREATED WITH ABATACEPT: DATA FROM A LARGE POOLED ANALYSIS OF 4 RCTS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Abatacept; Rheumatoid arthritis; Internal medicine; Adalimumab; Rheumatoid factor; Autoantibody; Methotrexate; Population; Clinical trial; Randomized controlled trial; Immunology; Rituximab; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01553551,0.002501005,0.009159474,0.0009221099,0.000602462,0.003277799,0.001060009,0.00266841,0.004541673],"category_scores_gemma":[0.019978,0.001172886,0.02514784,0.001681375,0.001266768,0.002143918,0.001304966,0.002731181,0.0006327161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008171974,"about_ca_system_score_gemma":0.0009562543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001831209,"about_ca_topic_score_gemma":0.003901129,"domain_scores_codex":[0.9842089,0.01078288,0.001954036,0.001613736,0.000803754,0.0006365917],"domain_scores_gemma":[0.9829329,0.01166286,0.002636434,0.001686691,0.0007124926,0.000368611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2456473,0.0001989565,0.01862616,0.02011517,0.6883102,0.0001913837,0.0001016232,0.001031593,0.001774611,0.0002160324,0.001248547,0.02253846],"study_design_scores_gemma":[0.08300052,0.00802995,0.05115447,0.002153848,0.8504487,0.0001688606,0.0001587523,0.0007116169,0.0005778843,0.001114811,0.002375458,0.0001051833],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4800089,0.4973563,0.006836578,0.001331443,0.002467928,0.0009515793,0.004515607,0.0003165641,0.006215169],"genre_scores_gemma":[0.9808834,0.01402874,0.001333761,0.0009886721,0.0005329454,0.000279494,0.00127003,0.00005427087,0.0006286051],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01553551,"threshold_uncertainty_score":0.08216065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05013095158934038,"score_gpt":0.369493252303994,"score_spread":0.3193623007146536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}