{"id":"W3164180422","doi":"10.3389/fcell.2021.640200","title":"Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Senescence; Chromosome; Biology; Chromosome segregation; Cell biology; Mitosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134236,0.0002004973,0.0001794407,0.000330496,0.0002126903,0.0003577902,0.0001631036,0.0003023588,0.001909191],"category_scores_gemma":[0.0001449489,0.0001388534,0.0001659818,0.0002201317,0.0002292019,0.0002684281,0.0002043954,0.0004574751,0.0005324049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520324,"about_ca_system_score_gemma":0.0001959348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532902,"about_ca_topic_score_gemma":0.001990051,"domain_scores_codex":[0.9998879,0.000006425537,0.000008308651,0.00003870124,0.00004209064,0.00001651689],"domain_scores_gemma":[0.999817,0.00002149024,0.00005303503,0.00002845885,0.00003691062,0.00004318121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000438112,0.000004917262,0.0009593744,0.00002701017,0.000002888218,0.00004850244,0.00003130087,0.00001427647,0.9971855,0.00005138119,0.00002329446,0.001607609],"study_design_scores_gemma":[0.000007000493,0.0002166963,0.153723,0.00001391101,0.00002351867,0.001225989,0.0001830908,0.0005059122,0.8368509,0.0001747507,0.007062437,0.00001274643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832535,0.006130332,0.006408741,0.0001279865,0.00005691719,0.00001594378,0.0009945544,0.0001252733,0.002886626],"genre_scores_gemma":[0.9917212,0.001178021,0.001650622,0.00005585537,0.00001140621,0.00002412678,0.0008306006,0.00002622617,0.004501918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909191,"threshold_uncertainty_score":0.006386876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502251400704676,"score_gpt":0.2660108789104561,"score_spread":0.2509883649034094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}